西维来司他钠致高胆红素血症一例
Hyperbilirubinemia caused by sivelestat sodium:a case report
刘晓蒙 1訾铁生2
作者信息
- 1. 涿州市医院 药学部,河北 涿州 072750
- 2. 涿州市医院 重症医学科,河北 涿州 072750
- 折叠
摘要
本文报道1例急性呼吸窘迫综合征患者使用西维来司他钠治疗后出现胆红素升高,皮肤及巩膜黄染,不伴有转氨酶异常.临床药师对其临床症状与药物关联性进行分析,考虑为西维来司他钠引起的不良反应,建议停药.停用西维来司他钠后,患者胆红素水平逐渐下降,停药6 d后基本恢复正常.此案例提示临床应用西维来司他钠疗程超过5 d时,应监测患者胆红素水平,以确保用药安全.
Abstract
This article reported a case of a patient who was treated with sivelestat sodium due to acute respiratory distress syndrome,resulting in elevation of serum bilirubin and yellow staining of skin and sclera,while not accompanied by abnormal transaminase.Clinical pharmacists analyzed the relevance between clinical symptoms and drugs,considered it as an adverse reaction caused by sivelestat sodium and suggested the withdrawal of sivelestat sodium.After discontinuation of sivelestat sodium,bilirubin level of the case gradually decreased and basically recovered after 6 days of withdrawal.It was suggested that bilirubin level should be monitored when patients were treated with sivelestat sodium for more than 5 days to ensure drug safety.
关键词
西维来司他钠/高胆红素血症/不良反应Key words
sivelestat sodium/hyperbilirubinemia/adverse reaction引用本文复制引用
出版年
2024
NETL
NSTL
万方数据