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《中国急性缺血性卒中诊治指南2023》治疗策略解析

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《中国急性缺血性卒中诊治指南2023》(简称新指南)对急性缺血性卒中的诊治策略进行了全面更新,旨在优化患者治疗策略,提高治疗效果,降低致残率和死亡率。新指南在秉承个体化治疗原则的基础上,引入了诸多创新举措。其中,新型溶栓药物替奈普酶的纳入及治疗时间窗的扩展,为血管再通治疗带来了新突破。同时,新指南还涵盖了生命支持与基础管理、抗血小板治疗、抗凝治疗、康复治疗以及急性期并发症处理等多个关键方面。具体而言,在生命支持与基础管理部分,新指南强调了呼吸、心脏、体温、血压和血糖的个体化管理策略;在血管再通治疗方面,不仅引入了替奈普酶,还详细阐述了血管内介入治疗的最新策略,进一步扩展了治疗的可能性;抗血小板和抗凝治疗部分,则提供了更为精细化的治疗方案,并突出了个体化评估的重要性;在康复治疗方面,新指南强调了早期康复对于患者预后的积极影响;而对于急性期并发症的处理,新指南也给出了针对脑水肿、癫痫、肺炎及深静脉血栓形成等常见并发症的具体建议。与国内外既往指南相比,新指南既保持了一致性,又展现出了中国特色和创新精神。通过遵循新指南的建议,临床医生能够更精准地选择治疗方案,为患者带来更好的预后。本文对新指南治疗策略进行解析。
Analysis of Treatment Strategies in the"2023 Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke"
The"2023 Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke"(referred to as the new guidelines)have comprehensively updated the diagnostic and treatment strategies for acute ischemic stroke,with the aim of optimizing patient treatment strategies,improving therapeutic outcomes,and reducing disability and mortality rates.Adhering to the principle of individualized treatment,the new guidelines introduce a series of innovative approaches.Notably,the incorporation of the novel thrombolytic agent tenecteplase and the extension of the therapeutic time window mark significant advancements in vascular recanalization therapy.Furthermore,the new guidelines encompass multiple crucial aspects,including life support and basic management,antiplatelet therapy,anticoagulant therapy,rehabilitation therapy,and the management of acute-phase complications.Specifically,in the domain of life support and basic management,the new guidelines emphasize individualized management strategies for respiratory function,cardiac care,temperature control,blood pressure regulation,and glycemic control.In the realm of vascular recanalization therapy,not only is tenecteplase introduced as a new therapeutic option,but the latest advancements in endovascular interventional therapy are also detailed,thereby broadening the spectrum of treatment possibilities.Regarding antiplatelet and anticoagulant therapy,the new guidelines provide more refined treatment algorithms and underscore the importance of individualized assessment and tailored therapy.In the area of rehabilitation therapy,the new guidelines highlight the profound positive impact of early rehabilitation on patient outcomes.For the management of acute-phase complications,the new guidelines offer specific and evidence-based recommendations for addressing common complications such as cerebral edema,seizures,pneumonia,and deep vein thrombosis.Compared to previous guidelines both domestically and internationally,the new guidelines maintain consistency while demonstrating Chinese characteristics and an innovative spirit.By following the recommendations of the new guidelines,clinicians can more accurately select treatment options,leading to better patient outcomes.This article provides an analysis of the treatment strategies outlined in the new guidelines.

acute ischemic strokestrokepersonalized treatment

赵玲娟、刘岩、文力

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首都医科大学附属北京胸科医院 急诊科,北京 101149

急性缺血性卒中 卒中 治疗策略 个体化

2024

临床药物治疗杂志
北京药学会

临床药物治疗杂志

CSTPCD
影响因子:1.07
ISSN:1672-3384
年,卷(期):2024.22(11)