Glucagon-like peptide-1 receptor agonists:clinical applications and research progress
Glucagon-like peptide-1(GLP-1)receptor agonists represent a novel class of antihyperglycemic drugs,which differ from traditional antihyperglycemic drugs in their mechanisms of action and are now widely used in the treatment of type 2 diabetes mellitus(T2DM).As clinical evidence continues to accumulate,numerous domestic and international guidelines recommend the use of GLP-1 receptor agonists(GLP-1RAs)for T2DM management.Currently,10 GLP-1RAs have been marketed in China.These drugs exhibit variations in pharmacokinetics and pharmacodynamics due to differences in their structural homology with native GLP-1.This article summarizes the pharmacokinetic characteristics,clinical applications,including domestic and international indications,adverse reactions,and considerations of GLP-1RAs.
glucagon-like peptide-1 receptor agoniststype 2 diabetes mellituspharmacokinetics,pharmacodynamicsrational use of drugs
NETL
NSTL
万方数据
