Chapter 4 Guideline for the Evaluation of Drug Pharmaceutical Properties in vivo
This chapter introduces the key points for evaluating the pharmaceutical properties of drugs in vivo,including pharmacokinetics and pharmacodynamics.Pharmacokinetics mainly explains the changes and laws in the absorption,distribution,metabolism,and excretion of drugs in the body,while pharmacodynamics refers to the relationship between the concentration of drugs at the site of action and pharmacological effects or adverse reactions in vivo.In clinical practice,based on the characteristics and parameters of drug action in the body,combined with the influence of patient physiology,pathology,and other factors,medication regimens are formulated and adjusted to ensure safe,effective,and rational use of drugs.Other effects of the pharmaceutical properties of drugs in vivo include their impact on drug interactions,their relationship with medication in special populations,and their critical role in new drug development,drug formulation improvement,bioavailability and bioequivalence research.
drug pharmaceutical properties in vivopharmacokineticspharmacodynamics
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