Evaluation of the rationalality of cefoperazone-sulbactam in neonatal department based on children drug utilization index
Objective To investigate the use of cefoperazone-sulbactam for injection in the neonatal department of a hospital using the children's drug utilization index(children drug utilization index,cDUI)and provide areference for optimizing neonatal drug utilization.Methods We extracted data from 74 neonates who received cefoperazone-sulbactam in 2023.The cDUI was calculated to determine drug utilization rationality,and the relationship between cefoperazone-sulbactam use and factors such as gestational age,postnatal age,combination therapy,dosage,white blood cell count,C-reactive protein value,and neutrophil ratio.Results Among the 74 neonates,26 were premature infants and 48 were full-term.There was no statistically significant difference in cDUI values across different gestational age groups(P>0.05).A comparison of cDUI between 70 perinatal neonates(94.29%)and 4 non-perinatal neonates(5.71%)showed no significant linear trend in cDUI with increasing age.Fifty-five neonates(74.32%)received combination therapy with cefoperazone-sulbactam and penicillin sodium,while 19(25.68%)received cefoperazone-sulbactam alone,with no significant difference in cDUI between these groups(P>0.05).Dosages were 30-60 mg/(kg·d)for 21 neonates(28.38%)and>60 mg/(kg·d)for 53 neonates(71.62%),with a maximum dosage of 92 mg/(kg·d),administered every 12 hours.The difference in cDUI between these dosage groups was statistically significant(P<0.05).Among the enrolled neonates,19(25.68%)had cDUI values within 0.9-1.1,12(16.22%)had cDUI<0.9,and 43(58.10%)had cDUI>1.1.White blood cell count,CRP level,and neutrophil ratio showed no significant effect on cDUI values.Conclusion Gestational age,postnatal age,combination therapy,white blood cell count,C-reactive protein value,and neutrophil ratio had no significant effect on cDUI value,except for dosage.There were instances of suboptimal or excessive dosing of cefoperazone-sulbactam among the neonates,indicating potential irrationality in its application in the neonatal department.
children drug utilization indexneonatescefoperazone-sulbactamrational drug use evaluation
NETL
NSTL
万方数据
