Comparative analysis of preparation methods of intravenous antibacterial drug instructions
Objective The study aimed to investigate the standardization of preparation instructions described in package inserts for intravenous antibiotics and compare existing differences.Methods Package inserts for intravenous antibacterial from two tertiary hospitals were collected and analyzed for preparation methods,contraindications,single dosage,dosing frequency,preparation concentration,compatible solvents,shaking time,resting time,infusion rate,sequential infusion requirements,flushing requirements,as well as storage conditions for the original drug,reconstituted solutions,and final products.Annotation rates,level of detail and position of information were evaluated.a detailed comparison was made among 8 groups of instructions with the same generic name from different manufacturers.Results A total of 298 entries on preparation methods and related information were extracted.Dosing frequency annotations were most complete,while compatible solvents,single dosage,compatibility contraindications,and infusion rates were also detailed.However,information on shaking time,resting time,and flushing requirements was sparse and lacked detailed instructions.Preparation methods primarily listed in the dosage and administration section,while compatibility contraindications and storage conditions were inconsistently placed.Minimal differences were observed among inserts from different manufacturers of the same generic drugs,with notable variations found for cefuroxime and teicoplanin.Conclusion There has been marked improvement in the labeling of intravenous drug package inserts;however,standardization is still needed for labeling positions of compatibility contraindications and storage conditions of final preparations.The inclusion and detailing of shaking time,resting time,infusion rate,and flushing requirements require further refinement.
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