Change and its clinical significance of the ratio of N-acetyl-β-D-glocosaminidase to urine creatinine in patients with lupus nephritis
Objective To investigate the change of the ratio of N-acetyl-β-D-glocosaminidase(NAG)to urine creatinine(UCr)in patients with lupus nephritis(LN)and analyze its clinical significance.Methods A prospective study was conducted,including 80 patients with systemic lupus erythematosus who received treatment at Henan Provincial People's Hospital from December 2020 to December 2022 as the study subjects.The levels of NAG and UCr were detected,and the patients were divided into LN group and non LN group by clinical symptom evaluation and laboratory examination.Forty healthy individuals were included as a blank control group during the same period.The expression of NAG/UCr was compared among the three groups.The relationship between NAG/UCr expression and the occurrence of LN in patients with systemic lupus erythematosus was analyzed.Results After clinical evaluation,43 cases out of 80 patients with systemic lupus erythematosus developed LN,accounting for 53.75％(43/80).There were 37 cases without LN,accounting for 46.25％(37/80).The levels of NAG and NAG/UCr in the LN group were higher than those in the non LN group and blank control group,while the level of UCr was lower than those in the non LN group and blank control group,with significant differences(P＜0.05).The NAG,NAG/UCr levels in the non LN group were higher than those in the blank control group,while the UCr level was lower than that in the blank control group,with significant differences(P＜0.05).Through point two column correlation analysis,NAG,NAG/UCr were positively correlated with the occurrence of LN(r＞0,P＜0.05),while UCr was negatively correlated with the occurrence of LN(r＜0,P＜0.05).Conclusions NAG/UCr is highly expressed in LN patients and positively correlated with the occurrence of LN in patients with systemic lupus erythematosus.The higher the NAG/UCr,the greater the likelihood of LN occurrence.
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