Relationship of EGFR level in tumor tissue with its tumor stage,pathological grade,lymph node metastasis,and postoperative recurrence in lung adenocarcinoma
Objective To investigate the relationship between epidermal growth factor receptor(EGFR)levels in tumor tissues of lung adenocarcinoma and tumor stage,pathological grade,lymph node metastasis,and postoperative recurrence.Methods The surgical specimens and clinical data were collected from 86 patients with lung adenocarcinoma from November 2019 to November 2022,including tumor stage,pathological grade,lymph node metastasis,and recurrence within one year after surgery.The expression level of EGFR in tumor tissues was quantitatively evaluated using immunohistochemical staining,and the relationship between EGFR positivity and tumor stage,pathological grade,lymph node metastasis,and postoperative recurrence in lung adenocarcinoma patients was analyzed.Results Among the 86 patients with lung adenocarcinoma,50 cases showed EGFR-positive expression in tumor tissues.There was a significant relationship between EGFR expression levels in tumor tissue and tumor stage,pathological grade,preoperative lymph node metastasis,and postoperative recurrence(P＜0.05).EGFR positive expression was more commonly observed in early-stage(stage Ⅰ and Ⅱ)and low-grade(grade Ⅰ and Ⅱ)lung adenocarcinomas.Lung adenocarcinoma patients with EGFR positive expression had lower incidence of preoperative lymph node metastasis and postoperative recurrence.Conclusions The positive expression of EGFR in lung adenocarcinoma is correlated with tumor stage,pathological grade,preoperative lymph node metastasis and postoperative recurrence,which provides a new clue for molecular diagnosis and treatment of lung adenocarcinoma.
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