Comparision of efficacy and safety of three-dimensional conformal radiotherapy and intensity modulated radiation therapy on intracranial germ cell tumors in children
Objective To compare the clinical efficacy and clinical safety of three-dimensional conformal radiotherapy and intensity modulated radiation therapy on intracranial germ cell tumors in children.Methods Sixty-eight children with central nervous system germ cell tumors(CNS-GCTs)in the Third Hospital of Zhengzhou from January 2016 to June 2022 were enrolled,and they were assigned into two groups according to different radiotherapy modalities.The study group(n=30)was given intensity modulated radiation therapy(IMRT),while the control group(n=38)received three-dimensional conformal radiotherapy(3DCRT).Then the plan delivery efficiency,dosimetric parameters of planning target volume(PTV),serum levels of alpha fetoprotein(AFP)and β-human chorionic gonadotropin(β-HCG),radiation dose to the hippocampus and planned exposure dose to organs at risk were compared between the two groups.Results The study group had smaller number of monitor units,shorter treatment time and higher Gamma pass rate than those of the control group,with significant differences(P＜0.05).The dosimetric parameters D98％and homogeneity index(HI)were smaller in study group than those in control group(P＜0.05).There was no significant differences in serum β-HCG and AFP levels after radiotherapy yielded between the two groups(P＞0.05).The protection of lens,thyroid and kidney in the study group was better than that in the control group,and the differences were significant(P＜0.05).Conclusions Compared with 3DCRT,the application of IMRT in CNS-GCTs in children obtains better treatment efficiency in terms of the dosimetric distribution of planning area and protection of organs at risk.
Pediatric central nervous system tumorsGerm cell tumorsintensity modulated radiation therapyThree-dimensional conformal radiotherapyClinical efficacyPrognosis
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