Expressions of serum FⅩⅢ,TK1 and vWF in acute leukemia patients with thrombocytopenia after chemotherapy and their relationship with the bleeding
Objective To investigate the expressions of plasma coagulation factor ⅩⅢ(FⅩⅢ),thymidine kinase 1(TK1),von Willebrand factor(vWF)and their relationship with the degree of bleeding in acute leukemia(AL)patients with thrombocytopenia after chemotherapy.Methods Eighty-seven AL patients with thrombocytopenia after chemotherapy admitted to Anyang District Hospital from January 2020 to December 2022 were selected as the AL group,another 52 healthy individuals who underwent physical examinations during the same period were selected as the control group.The AL patients were divided into bleeding group(56 cases)and non-bleeding group(31 cases)according to whether there was bleeding.Enzyme linked immunosorbent assay(ELISA)was used to detect the expression levels of plasma FⅩⅢ TK1,and vWF in the different groups,and analyze the relationship between plasma FⅩⅢ TK1,vWF expression levels and bleeding severity.Results The plasma TK1 and vWF levels in the AL group were higher than those in the control group,while FⅩⅢ levels were lower than those in the control group(P＜0.05).The probability of platelet(PLT)≤10 x 109/L and plasma TK1 and vWF levels in bleeding group were higher than those in non-bleeding group,and plasma FⅩⅢ levels were lower than those in non-bleeding group(P＜0.05).The plasma levels of FⅩⅢ,TK1 and vWF were significantly different among patients with different bleeding degrees,and with the increase of bleeding score,the plasma levels of FⅩⅢ were gradually decreased,and the levels of TK1 and vWF were gradually increased(P＜0.05).Spearman correlation analysis showed that the bleeding score of AL patients was negatively correlated with FⅩⅢ(r=-0.681,P＜0.001),and positively correlated with TK1 and vWF(r=0.637,0.711,P＜0.001).Conclusions The expression level of plasma FⅩⅢ in patients with thrombocytopenic acute leukemia is low,and the expression levels of TK1 and vWF are high,three of which can effectively evaluate the degree of bleeding in patients.
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