Predictive value of serum IL-6,IL-17 levels and ROMA index for postoperative recurrence in patients with epithelial ovarian cancer
Objective To investigate the predictive value of serum interleukin-6(IL-6),IL-17 levels and risk of ovarian malignancy algorithm(ROMA)index for postoperative recurrence in patients with epithelial ovarian cancer.Methods From January 2020 to January 2021,90 patients with epithelial ovarian cancer who were scheduled to undergo tumor cytoreductive surgery in Luohe Central Hospital were selected as research subjects.The serum IL-6 and IL-17 levels were measured at admission,and ROMA index was calculated.After 2 years of follow-up,the postoperative recurrence of the patients was counted,and the patients were divided into recurrence group and non-recurrence group according to the postoperative recurrence.The clinical data,serum IL-6,IL-17 levels and ROMA index were compared between the two groups.Logistic regression model was used to analyze the risk factors of postoperative recurrence in patients with epithelial ovarian cancer.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum IL-6,IL-17 levels and ROMA index for postoperative recurrence in patients with epithelial ovarian cancer.Results Following up for 2 years,29 patients out of 90 patients with epithelial ovarian cancer experienced postoperative recurrence(32.22％)and 61 patients out of them did not experience recurrence(67.78％).The levels of serum carbohydrate antigen 125(CA125),human epididymal protein 4(HE4),IL-6,IL-17,and ROMA index in the recurrence group were higher than those in the non recurrence group,with significant differences(P＜0.05).The results of Logistic regression analysis showed that elevated levels of CA125,HE4,IL-6,IL-17,and ROMA index were all risk factors for postoperative recurrence in patients with epithelial ovarian cancer(OR＞1,P＜0.05).ROC curve was drawn,and the area under the curve(AUC)of serum IL-6,IL-17,ROMA index alone and combined to predict postoperative recurrence in patients with epithelial ovarian cancer was 0.757,0.749,0.737 and 0.882,respectively.Conclusions Upregulation of serum IL-6,IL-17,and ROMA index levels is correlated with an increased risk of postoperative recurrence in patients with epithelial ovarian cancer.Preoperative detection of serum IL-6,IL-17,and ROMA index levels before tumor cell depletion surgery can help predict the risk of postoperative recurrence in patients with epithelial ovarian cancer.
Ovarian cancerTumor cell reduction surgeryInterleukin-6Interleukin-17Risk of ovarian malignancy algorithm indexRecurrence
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