经肝动脉化疗栓塞术治疗不同类型肝癌的效果
Efficacy of transhepatic arterial chemoembolization on different types of hepatocellular carcinoma
穆歌 1冯雯雯 1陈珂 1朱艳1
作者信息
- 1. 郑州大学附属肿瘤医院(河南省肿瘤医院)微创介入二科,郑州 450003
- 折叠
摘要
目的 探讨经肝动脉化疗栓塞术治疗不同类型肝癌的效果.方法 选择2020年1月至2022年1月河南省肿瘤医院收治的90例肝癌患者为研究对象.将52例原发性肝癌患者纳入原发组,38例继发性肝癌患者纳入继发组.两组均行经肝动脉化疗栓塞术,比较两组患者近期疗效、肝功能指标[天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素指标(TBIL)、结合胆红素(DBIL)、白蛋白(ALB)、凝血酶原时间(PT)]以及患者6个月、12个月的生存预测情况.结果 原发组近期疗效与继发组比较,差异未见统计学意义(P＞0.05).治疗前两组患者肝功能指标比较,差异未见统计学意义(P＞0.05);治疗1个月后原发组TBIL、DBIL、ALB、PT水平均高于继发组,AST、ALT水平低于继发组(P＜0.05).两组患者治疗后6个月、12个月的生存预测情况比较,差异未见统计学意义(P＞0.05).结论 原发性与继发性肝癌患者经肝动脉化疗栓塞术治疗后均可有效改善近期疗效,原发性肝癌患者的肝功能各指标得到明显提升.
Abstract
Objective To investigate the efficacy of transcatheter arterial chemoembolization on different types of liver cancer.Methods Ninety liver cancer patients admitted to Henan Tumor Hospital from January 2020 to January 2022 were selected.The 52 patients with primary liver cancer were enrolled in the primary group and the 38 patients with secondary liver cancer were enrolled in the secondary group.Both groups underwent transarterial chemoembolization.The short-term efficacy,liver function indicators[aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin index(TBIL),bound bilirubin(DBIL),albumin(ALB),prothrombin time(PT)],and 6-month and 1-year survival predictions of the two groups were compared.Results There was no significant difference in the short-term efficacy between the primary group and the secondary group(P＞0.05).There was no significant difference in liver function indicators between the two groups before treatment(P＞0.05).After 1 month of treatment,the levels of TBIL,DBIL,ALB,PT in the primary group were higher than those in the secondary group,and the levels of AST and ALT were lower than those in the secondary group(P＜0.05).There was no significant difference in the survival prediction of 6 months and 12 months after treatment between the two groups(P＞0.05).Conclusions Patients with primary and secondary liver cancer can effectively improve their short-term efficacy after hepatic artery chemoembolization treatment,and the liver function indicators of patients with primary liver cancer have been significantly improved.
关键词
经肝动脉化疗栓塞/原发性肝癌/继发性肝癌/疗效Key words
Transhepatic artery chemoembolization/Primary hepatocellular carcinoma/Secondary hepatocellular carcinoma/Efficacy引用本文复制引用
出版年
2024
NETL
NSTL
万方数据