Effect of different 5-HT3 receptor antagonists on preventing chemotherapy-induced nausea and vomiting in patients with acute myeloid leukemia
Objective To investigate the effect of different 5-hydroxytryptamine type 3(5-HT3)receptor antagonists on preventing chemotherapy-induced nausea and vomiting in patients with acute myeloid leukemia.Methods Seventy-two patients with acute myeloid leukemia in Anyang District Hospital from September 2020 to January 2023 were enrolled,and randomly classified into two groups,with 36 cases in each group.The control group was treated with tropisetron,while the observation group was treated with palonosetron.The levels of 5-HT,dopamine(DA),grading of vomiting and nausea symptoms and Karnofsky Performance Status(KPS)grade were observed.The efficacy of preventing vomiting between two groups were compared.Results After treatment,the levels of 5-HT and DA in both groups decreased,and the KPS scores increased,and the changes in the observation group were greater than those in the control group(P＜0.05).Before treatment,there was no significant difference in the grades of nausea and vomiting between the two groups(P＞0.05).After treatment,the grades of nausea and vomiting in the observation group were significantly better than those in the control group,the overall effect of preventing vomiting was significantly better than that of the control group(P＜0.05).There was no significant difference in the remission of symptoms between the two groups at 24 hours after chemotherapy(P＞0.05).The remission of symptoms in the observation group was significantly better than that in the control group at 48,72 and 120 hours after chemotherapy(P＜0.05).Conclusions Compared with tropisetron,palonosetron has a better effect on preventing nausea and vomiting reactions in AML patients after chemotherapy.
5-hydroxytryptamine 3 receptor antagonistAcute myeloid leukemiaNausea and vomiting
NETL
NSTL
万方数据
