Correlation of serum levels of aPOA1 and S100β with cognitive function and prognosis in acute cerebral infarction patients
Objective To investigate the correlation of serum levels of apolipoprotein A1(aPOA1),central nervous specific protein(S100β)with cognitive function and prognosis in patients with acute cerebral infarction(ACI).Methods The clinical data of 120 ACI patients admitted to Nanyang Central Hospital from June 2022 to June 2023 were retrospectively studied.After 3 months of follow-up,the modified Rankin scale was used to evaluate the prognosis of patients.The patients with poor prognosis were included in the poor prognosis group(n=44),and the patients with good prognosis were included in the good prognosis group(n=76).All patients received serum aPOA1 and S100βdetection.The baseline data of the two groups were statistically analyzed.The correlation of serum aPOA1,S100β with cognitive function(MoCA score)in ACI patients was analyzed by bivariate correlation Pearson(N).Binary Logistic regression was used to analyze the relationship between serum aPOA1,S100β and the prognosis of ACI patients.Results The proportion of patients with hypertension and diabetes in the poor prognosis group was higher than that in the good prognosis group,and the level of serum aPOA1 was lower than that in the good prognosis group,the level of serum S100β was higher than that in the good prognosis group(P＜0.05).The MoCA score was(24.64±3.49)points in the poor prognosis group and(27.61±2.01)points in the good prognosis group,the difference was significant(t=5.923,P＜0.001).The results of bivariate correlation Pearson(N)analysis showed that serum aPOA1 was positively correlated with MoCA score in ACI patients(r＞0,P＜0.05),and serum S100β was negatively correlated with MoCA score in ACI patients(r＜0,P＜0.05).Binary logistic regression analysis showed that hypertension and high expression of serum S100β were risk factors for poor prognosis in ACI patients(OR＞1,P＜0.05),and high expression of serum aPOA1 was a protective factor for poor prognosis in ACI patients(OR＜1,P＜0.05).Conclusions The levels of serum aPOA1 and S100β are closely correlated with the cognitive function and prognosis of ACI patients.The cognitive function and prognosis can be evaluated by detecting the levels of aPOA1 and S100β.
Acute cerebral infarctionApolipoprotein A1Central nervous specific proteinCognitive functionPrognosis
万方数据
维普
