Changes of coagulation function indexes and their relationship with pathological characteristics and prognosis in patients with endometrial carcinoma
Objective To investigate the changes of coagulation function indexes and their relationship with pathological characteristics and prognosis in patients with endometrial carcinoma(EC).Methods Sixty-four EC patients admitted to Zhengzhou University Affiliated People's Hospital from April 2020 to April 2021 were selected as the EC group,another 64 patients with benign endometrial lesions in Zhengzhou University Affiliated People's Hospital during the same period were selected as the control group.The coagulation function indicators[platelets(PLT),fibrinogen(FIB),and D-dimer(D-D)]between the two groups were compared,and the relationship between the expression levels of coagulation function indicators and the pathological characteristics and prognosis of EC patients were analyzed.Results Compared with the control group,the coagulation function indicators in the EC group were higher(P＜0.05).The overexpression of PLT was not related to the age,menopause,hypertension,hyperlipidemia,diabetes,coronary heart disease,pathological grade,clinical stage and lymph node metastasis of EC patients(P＞0.05).High expression of FIB is correlated with pathological grading,clinical staging,and lymph node metastasis in EC patients(P＜0.05).High expression of D-D is correlated with pathological grading,clinical staging,and lymph node metastasis in EC patients(P＜0.05).The 2-year survival rates of EC patients with high FIB and D-D expression were lower than those of EC patients with low expression of FIB and D-D(P＜0.05).Conclusions The coagulation function indexes are increased in EC patients,which are closely correlated with pathological characteristics and prognosis.
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