Application of remifentanil combined with propofol anesthesia in thyroidectomy and its impact on the cardiovascular system during extubation
Objective To investigate the application of remifentanil combined with propofol anesthesia in thyroidectomy and its impact on the cardiovascular system during extubation.Methods Ninty-four patients who underwent thyroidectomy from September 2021 to February 2023 were selected as the study subjects.According to the random number table method,they were divided into a control group and an observation group,with 47 cases in each group.The control group was given intravenous anesthesia primarily with propofol,and the observation group received anesthesia with remifentanil combined with propofol.The cardiovascular system indicators[systolic blood pressure(SBP),diastolic blood pressure(DBP),heart rate(HR),blood oxygen saturation(SpO2)],anesthesia recovery time,stress response indicators[adrenocorticotropic hormone(ACTH),reactive oxygen species(ROS),and catechol O-methyltransferase(COMT)]levels during extubation period[induction of anesthesia(T0),immediately extubation(T1),5 min after extubation(T2),10 min after extubation(T3)]in the two groups were evaluated.Results At T1,T2,and T3,all indicators within the group were better than those at T0,and the SBP,DBP,and HR in the observation group were lower than those in the control group at T1,T2,and T3,while SpO2 was higher than that in the control group(P＜0.05).The recovery time of anesthesia in the observation group was lower than that in the control group(P＜0.05).24 hours after surgery,the ACTH,ROS,and COMT levels in the observation group were lower than those in the control group(P＜0.05).Conclusions The combination of remifentanil and propofol is well applied in thyroidectomy,which can reduce the patient's anesthesia recovery time,improve the stability of cardiovascular system indicators,and reduce the patient's postoperative stress response level.
ThyroidectomyRemifentanilPropofolExtubation periodCardiovascular system
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