Comparison of the efficacy of α-lipoic acid combined with epalrestat and pancreatic kininogenase respectively on diabetes mellitus complicated by peripheral neuropathy
Objective To compare the efficacy of α-lipoic acid combined with epalrestat and pancreatic kininogenase respectively on diabetes mellitus complicated by peripheral neuropathy.Methods One hundred and thirty-two cases of diabetes mellitus complicated by peripheral neuropathy admitted to the Central Hospital of Luoyang from January 2021 to December 2022 were selected and divided into control group and observation group,with 66 cases in each group.The observation group was treated with α-lipoic acid combined with epalrestat,and the control group was treated with α-lipoic acid combined with pancreatic kininogenase.The clinical efficacy,nerve conduction velocity[motor nerve conduction velocity(MCV),sensory nerve conduction velocity(SCV)of median nerve and common peroneal nerve],oxidative stress index[malondialdehyde(MDA),8-hydroxyldeoxyguanosine(8-OHdG),superoxide dismutase(SOD)]levels,inflammatory factor[cystatin C(Cys C),interleukin-17(IL-17),hypoxia-inducing factor-1α(HIF-1α)]levels and treatment safety were evaluated in the two groups.Results The total effective rate in the observation group was 92.42％(61/66),which was higher than that in the control group[77.27％(51/66)](P＜0.05).The SCV and MCV of median nerve and common peroneal nerve in the observation group were higher than those in the control group(P＜0.05).After treatment,the levels of malondialdehyde(MDA)and 8-hydroxydeoxyguanosine(8-OHdG)in the observation group were lower than those in the control group,and the levels of superoxide dismutase(SOD)was higher than that in the control group(P＜0.05).After treatment,the levels of serum cystatin C(Cys C),interleukin-17(IL-17)and hypoxia-inducible factor-1α(HIF-1α)were lower in the observation group than those in the control group(P＜0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusions The efficacy ofα-lipoic acid combined with epalrestat in the treatment of diabetes mellitus complicated by peripheral neuropathy is better than that of α-lipoic acid combined with pancreatic kininogenase,which can improve the nerve conduction velocity,reduce the level of oxidative stress,inhibit the occurrence of inflammatory response in patients,and has good therapeutic safety.
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