Predictive efficacy of serum UCP2 and HIF-1α levels on severity and disease outcome of neonatal pneumonia
Objective To investigate the predictive efficacy of serum uncoupling protein-2(UCP2)and hypoxia-inducing-factor-1α(HIF-1α)levels on severity and disease outoome of neonatal pneumonia(NP).Methods One hundred and three children with NP admitted to the neonatology department of the First Affiliated Hospital of Henan University of Science and Technology from January 2020 to December 2023 were selected as the study objects.According to the severity of the disease,the 103 children with NP were divided into mild group(n=64)and severe group(n=39).Then the children were divided into good group(n=82)and bad group(n=21)according to the disease outcome.Sixty healthy full-term neonates were selected as control group.The serum UCP2 and HIF-1αlevels were detected by enzyme-linked immunosorbent assay.Pearson correlation analysis was used to investigate the relationship between serum UCP2 and HIF-1α levels and the severity of NP disease,and the predictive value of serum UCP2 and HIF-1α levels on the disease outcome of children with NP was evaluated by receiver operating characteristic(ROC)curve.Results The serum UCP2 and HIF-1αlevels in severe group were significantly higher than those in control group and mild group,and those of the mild group were higher than those of the control group,the differences were significant(P＜0.05).Serum UCP2 and HIF-1α levels were positively correlated with the severity of NP(r=0.437,0.529,P＜0.001).Serum UCP2 and HIF-1α levels in good group were significantly lower than those in bad group(P＜0.05).The AUC(95％CI)of serum UCP2 and HIF-1α were 0.753(0.707～0.802)and 0.819(0.768～0.870),respectively,and the AUC(95％CI)of combined UCP2 and HIF-1α levels was 0.901(0.850～0.946).Conclusions Serum UCP2 and HIF-1α are highly expressed in children with NP,which are closely correlated with the disease and outcome of NP,and can be used as potential markers to predict the disease outcome of children with NP.
Newborn with pneumoniaSeverity of the illnessDisease outcomeUncoupling protein 2Hypoxia-inducible factor-1α
NETL
NSTL
万方数据
