Correlation of neutrophil-to-lymphocyte ratio,PD-L1 expression with the efficacy of immunotherapy for advanced non-small cell lung cancer
Objective To investigate the correlation of neutrophil-to-lymphocyte ratio(NLR),programmed death ligand 1(PD-L1)expression with the efficacy of immunotherapy in advanced non-small cell lung cancer(NSCLC).Methods A retrospective study was conducted to select the clinical data of 90 patients with advanced NSCLC admitted to Henan Provincial Chest Hospital from September 2020 to May 2023 who received immunotherapy.After 2 cycles of treatment,the clinical efficacy of the patients was evaluated,and then the patients were divided into the treatment effective group and the treatment ineffective group.The baseline data of the two groups were compared,and the risk factors affecting the efficacy of immunotherapy for advanced NSCLC were analyzed by binary Logistic regression.Results The percentage of patients with smoking index≥200,ECOG score of 2,low differentiation,high expression of PD-L1,and NLR ≥median was higher in the treatment ineffective group than that in the treatment effective group(P＜0.05).The results of the binary Logistic regression analysis showed that low differentiation,high expression of PD-L1 and NLR score of 1 were the risk factors(ORA)for the efficacy of immunotherapy in advanced NSCLC(OR=3.930,3.687,HR=2.974,2.731,P＜0.05).Conclusions NLR and PD-L1 expression are closely correlated with immunotherapy efficacy in patients with advanced NSCLC.
Non-small cell lung cancerImmunotherapyNeutrophil-to-lymphocyte ratioProgrammed death ligand 1
NETL
NSTL
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