摘要
目的 探讨2型糖尿病(T2DM)合并阿尔茨海默病(AD)患者血脂代谢指标的变化及其意义.方法 选择2019年2月至2021年12月河南大学第一附属医院收治的46例T2DM合并AD患者作为A组,选择同期49例单纯T2DM患者为糖尿病组(B组),选择38例AD患者为AD组(C组),选择65例健康体检者为对照组(D组),分析四组血脂[三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]水平;应用CDR评分标准评估A组患者的痴呆程度,比较A组不同痴呆程度患者血清TC、TG、LDL-C、HDL-C水平,分析血清TC、TG、LDL-C、HDL-C水平与T2DM合并AD患者痴呆程度的相关性;分析血脂代谢指标对T2DM合并AD的诊断价值.结果 四组TG、TC、LDL-C水平逐渐降低,HDL-C水平逐渐升高,差异有统计学意义(P＜0.05);A组随着痴呆程度的加重,血清HDL-C水平逐渐降低,TG、TC、LDL-C水平逐渐升高,差异有统计学意义(P＜0.05);Pearson相关性分析,血清TG、TC、LDL-C水平与CDR评分呈正相关,血清HDL-C水平与CDR评分呈负相关(P＜0.05);ROC曲线结果显示,血清TG、TC、LDL-C、HDL-C单独及联合应用诊断T2DM合并AD的AUC分别为0.819、0.895,0.881,0.842、0.950.结论 血清TG、TC、LDL-C、HDL-C联合检测在T2DM合并AD的诊断中有一定的应用价值.
Abstract
Objective To investigate the changes and significance of lipid metabolism indexes in patients with type 2 diabetes mellitus(T2DM)complicated with Alzheimer's disease(AD).Methods Forty-six patients with T2DM combined with AD admitted to the First Affiliated Hospital of Henan University from February 2019 to December 2021 were selected as group A,49 patients with T2DM alone at the same time were selected as group B,38 patients with AD were selected as group C,and 65 healthy people were selected as control group(group D).The levels of serum lipid[triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C)and high density lipoprotein cholesterol(HDL-C)]levels in the four groups were analyzed.CDR scoring criteria were used to evaluate the degree of dementia in group A.The levels of serum TC,TG,LDL-C and HDL-C in patients with different degrees of dementia in group A were compared,and the correlation between the levels of serum TC,TG,LDL-C and HDL-C with the degree of dementia in T2DM patients with AD was analyzed.The diagnostic value of lipid metabolism indexes in T2DM with AD was analyzed.Results The levels of TG,TC and LDL-C in the four groups gradually decreased,and the level of HDL-C gradually increased,with significant differences(P＜0.05).With the severity of dementia in group A,the serum HDL-C level gradually decreased,and the TG,TC,LDL-C levels gradually increased,the differences were significant(P＜0.05).By Pearson correlation analysis,the serum TG,TC and LDL-C levels were positively correlated with CDR score,while the serum HDL-C level was negatively correlated with CDR score.ROC curve results showed that the AUC of serum TG,TC,LDL-C and HDL-C alone and combined in the diagnosis of T2DM with AD were 0.819,0.895,0.881,0.842 and 0.950,respectively(P＜0.05).Conclusions The combined detection of serum TG,TC,LDL-C and HDL-C test has certain diagnostic value for T2DM combined with AD.
NETL
NSTL
万方数据