Therapeutic Value of Estrogen Receptor α in Hepatocellular Carcinoma Based on Molecular Mechanisms

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外文摘要：The incidence of hepatocellular carcinoma (HCC) is signifi-cantly lower in women than men, implying that estrogen receptors (ERs) may play an important role in this sex di-morphism. Recently, considerable progress has been made in expanding our understanding of the mechanisms of ERs in HCC. As one of the most important ERs, ERα functions as a tumor suppressor in the progression of HCC through various pathways, such as STAT3 signaling pathways, lipid metabolism-related signaling pathways, and non-coding RNAs. However, the function of ERα was reduced with the changes of some molecules in the liver, which may develop further into HCC and make it difficult to achieve an effective hormone treatment effect. Intriguingly, there are signs that individualized hormone therapy according to the activity of ERα will overcome this challenge. Based on these observa-tions, it is particularly imperative to reassess and extend the function of ERα. In this review, we mainly elucidated molecular mechanisms associated with ERα in HCC and investigated the individualized hormone therapy based on these mechanisms, with the aim of providing new insights for HCC treatment.

外文关键词：

Hepatocellular carcinomaEstrogen receptorMolecular mecha-nismHormone therapyPrecision medicine

作者：

Xiangzhe Meng、Xue Liu

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作者单位：

Second Clinical College,Jining Medical University,Jining,Shandong,China

Department of Pathology,College of Basic Medicine,Jining Medical University,Jining,Shandong,China

基金：

National Natural Science Fund for YouthResearch Fund for Lin He's Academician Workstation of New Medicine and Clinical Translation in Jining Medical UniversityDomestic Visiting Scholar Project for Core Teachers of Jining Medical University

项目编号：

81902518JY-HL2018MS02

出版年：

2022

DOI：

10.14218/JCTH.2021.00224

临床与转化肝病杂志(英文版)

ISSN：

年,卷(期)：2022.10(1)

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