首页|Irreversible Electroporation for Hepatocellular Carcinoma Abutting the Diaphragm: A Prospective Single-center Study

Irreversible Electroporation for Hepatocellular Carcinoma Abutting the Diaphragm: A Prospective Single-center Study

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Background and Aims: Irreversible electroporation (IRE) is an emerging local ablation therapy which may be effec-tive for unresectable tumors. This study aimed to evaluate the safety and efficacy of percutaneous IRE in the treat-ment of hepatocellular carcinoma (HCC) abutting the dia-phragm. Methods: A total of 26 participants with 39 tu-mors abutting the diaphragm were prospectively evaluated between July 2015 and September 2018. Complications associated with IRE were recorded, and the survival benefit of IRE was analyzed. The factors associated with time to local tumor progression (LTP) were analyzed using univari-ate and multivariate Cox regression models. Results: No major complications or treatment-related deaths occurred. The technical success rate was 96.2％ (25/26) and com-plete ablation rate was 92.3％ (36/39). The median follow-up period was 16.7 months (range: 3.0–43.0 months), the LTP occurred in 15.2％ of tumors and median time to LTP was 20.4 months. Overall, tumor size (hazard ratio: 1.24 [95％ confidence interval: 0.38, 3.81], p=0.03) was the only factor associated with time to LTP. Conclusions: This study shows for the first time that percutaneous IRE is a safe and effective ablation technology for HCC abutting the diaphragm.

Irreversible electroporationHepatocellular carcinomaDiaphragmSafetyEfficacy

Yangyang Ma、Zhixian Chen、Bing Liang、Rongrong Li、Jianyu Li、Zhonghai Li、Mao Lin、Lizhi Niu

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Central Laboratory,Affiliated Fuda Cancer Hospital,Jinan University,Guangzhou,Guangdong,China

Department ofOncology,Affiliated Fuda Cancer Hospital,Jinan University,Guangzhou,Guangdong,China

Department of Surgery and Anesthesia,Affiliated Fuda Cancer Hospital,Jinan University,Guangzhou,Guangdong,China

Department of Ultrasound,Affiliated Fuda Cancer Hospital,Jinan University,Guangzhou,Guangdong,China

Department of Radiology,Affiliated Fuda Cancer Hospital,Jinan University,Guangzhou,Guangdong,China

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International Science Foundation of Affiliated Fuda Cancer Hospital,Jinan University

Y2018-ZD-01

2022

10.14218/JCTH.2021.00019

临床与转化肝病杂志(英文版)

临床与转化肝病杂志(英文版)

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年,卷(期)：2022.10(2)
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