首页|Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease

Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease

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Background and Aims: We compared lung function parameters in nonalcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD), and examined the association between lung function parameters and fibrosis severity in MAFLD. Meth-ods: In this cross-sectional study, we randomly recruited 2,543 middle-aged individuals from 25 communities across four cities in China during 2016 and 2020. All participants received a health check-up including measurement of an-thropometric parameters, biochemical variables, liver ul-trasonography, and spirometry. The severity of liver dis-ease was assessed by the fibrosis (FIB)-4 score. Results: The prevalence of MAFLD was 20.4％ (n=519) and that of NAFLD was 18.4％ (n=469). After adjusting for age, sex, adiposity measures, smoking status, and significant alco-hol intake, subjects with MAFLD had a significantly lower predicted forced vital capacity (FVC, 88.27±17.60％ vs. 90.82±16.85％, p<0.05) and lower 1 s forced expiratory volume (FEV1, 79.89±17.34 vs. 83.02±16.66％, p<0.05) than those with NAFLD. MAFLD with an increased FIB-4 score was significantly associated with decreased lung function. For each 1-point increase in FIB-4, FVC was di-minished by 0.507 (95％ CI: ?0.840, ?0.173, p=0.003), and FEV1 was diminished by 0.439 (95％ CI: ?0.739, ?0.140, p=0.004). The results remained unchanged when the statistical analyses was performed separately for men and women. Conclusions: MAFLD was significantly asso-ciated with a greater impairment of lung function param-eters than NAFLD.

MAFLDNAFLDLung functionLiver fibrosis score

Lei Miao、Li Yang、Li-Sha Guo、Qiang-Qiang Shi、Teng-Fei Zhou、Yang Chen、Huai Zhang、Hui Cai、Zhi-Wei Xu、Shuan-Ying Yang、Hai Lin、Zhe Cheng、Ming-Yang Zhu、Xu Nan、Shuai Huang、Ya-Wen Zheng、Giovanni Targher、Christopher D Byrne、Yu-Ping Li、Ming-Hua Zheng、Cheng-Shui Chen

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Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China

Department of Gastroenterology,The Second Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China

The Interventional Pulmonary Key Laboratory of Zhejiang Province,Wenzhou,Zhejiang,China

NAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zheji-ang,China

Department of Biostatistics and Records Room,Medical Quality Management Office,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang,China

Department of Respiratory Medicine,Zhong Shan HospitalAffiliated to Shanghai Fudan University,Shanghai,China

Clinical Research Service Center,People's Hospital of HenanProvincial,Zhengzhou,Henan,China

Department of Respiratory and Critical Care Medicine,The Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shanxi,China

Department of Pulmonary and Critical Care Medicine,The Second Affili-ated Hospital of Fujian Medical University,Quanzhou,Fujian,China

Department of Pulmonary and Critical Care Medicine,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan,China

Section of Endocrinology,Diabetes and Metabolism,Department of Medicine,University and Azienda Ospedaliera Universitaria Integrata of Verona,Verona,Italy

Southampton National Institute for Health Research Biomedical Research Center,University Hospital Southampton,South-ampton General Hospital,Southampton,UK

Key Laboratory of Diagnosis and Treatment for The Development of Chronic Liver Disease in Zhejiang Province,Wenzhou,Zhejiang,China

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国家重点研发计划国家自然科学基金High Level Creative Talents from Department of Public Health in Zhejiang ProvinceKey Research and Development Program of Zhejiang ProvinceUniversity School of Medicine of Verona,Verona,ItalySouthampton National Institute for Health Research Biomedical Research Center

2016YFC1304000820006902019C03030

2022

10.14218/JCTH.2021.00306

临床与转化肝病杂志(英文版)

临床与转化肝病杂志(英文版)

ISSN：
年,卷(期)：2022.10(2)
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