首页|Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma
Prognostic Role and Potential Mechanisms of N6-methyladenosine-related Long Noncoding RNAs in Hepatocellular Carcinoma
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NETL
NSTL
维普
万方数据
Background and Aims: Numerous studies have explored the important role of N6-methyladenosine (m6A) in cancer. Nonetheless, the interaction between m6A and long noncod-ing RNAs (lncRNAs) is poorly investigated. Herein, we system-atically analyzed the role and prognostic value of m6A-related lncRNAs in hepatocellular carcinoma (HCC). Methods: The m6A-related lncRNAs were identified based on the correlation coefficients with m6A-related genes in HCC from The Cancer Genome Atlas. Subsequently, a novel risk score model was determined using the least absolute shrinkage and selection operator Cox regression analyses. Univariate and multivari-ate Cox analyses were used to identify independent prog-nostic factors for overall survival (OS) of HCC; thereafter, a prognostic nomogram was constructed. Results: A total of 259 lncRNAs showed significant correlations with m6A in HCC, while 29 lncRNAs had prognostic significance. Further, six critical m6A-related lncRNAs (NRAV, SNHG3, KDM4A-AS1, AC074117.1, AC025176.1, and AL031985.3) were screened out to construct a novel risk score model which classified HCC patients into high- and low-risk groups. Survival analy-ses revealed that patients in the high-risk group exhibited worse OS, both in the training and validation groups. The risk score was also identified as an independent prognostic factor of OS, and a nomogram was established and verified with superior prediction capacity. Besides, the risk score signifi-cantly correlated with the expression of immune checkpoint genes and immune subtypes. Conclusions: These findings indicated the significant role of m6A-related lncRNAs in HCC and the potential application of the novel risk score model for prognostic prediction.
Tianxing Dai、Jing Li、Linsen Ye、Haoyuan Yu、Mingbin Deng、Wei Liu、Hua Li、Yang Yang、Guoying Wang
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Department of Hepatic Surgery and Liver Transplant Program,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou,Guangdong,China
Department of Infectious Diseases and Hepatology Unit,Nanfang Hospital,Southern Medi-cal University,Guangzhou,Guangdong,China
Guangdong Key Laboratory of Liver Disease Research,The Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou,Guangdong,China
Guang-dong Natural Science FoundationGuang-dong Natural Science FoundationScience and Technology Program of Guangzhou CityGuangdong Key Laboratory of Liver Disease Research
NETL
NSTL
维普
万方数据
