首页|Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation

Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation

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Omics data address key issues in liver transplantation (LT) as the most effective therapeutic means for end-stage liver dis-ease. The purpose of this study was to review the current ap-plication and future direction for omics in LT. We reviewed the use of multiomics to elucidate the pathogenesis leading to LT and prognostication. Future directions with respect to the use of omics in LT are also described based on perspectives of surgeons with experience in omics. Significant molecules were identified and summarized based on omics, with a focus on post-transplant liver fibrosis, early allograft dysfunction, tumor recurrence, and graft failure. We emphasized the im-portance omics for clinicians who perform LTs and prioritized the directions that should be established. We also outlined the ideal workflow for omics in LT. In step with advances in technology, the quality of omics data can be guaranteed us-ing an improved algorithm at a lower price. Concerns should be addressed on the translational value of omics for better therapeutic effects in patients undergoing LT.

Multiomic analysisTranscriptomicsProteomicsMetabolomicsLiver transplantationEAD

Zhengtao Liu、Jun Xu、Shuping Que、Lei Geng、Lin Zhou、Adil Mardinoglu、Shusen Zheng

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Shulan International Medical College,Zhejiang Shuren University,Hangzhou,Zhejiang,China

Division of Hepatobiliaryand Pancreatic Surgery,Department of Surgery,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang,China

NHC Key Laboratory of Combined Multi-organ Transplantation,Key Laboratory of the diagnosis and treat-ment of organ Transplantation,CAMS,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang,China

Key Laboratory of Organ Transplantation

DingXiang Clinics,Hangzhou,Zhejiang,China

Key Laboratory of Organ Transplantation,Zhejiang Province,First Affiliated Hospital,School of Medicine,Zhejiang University,Hangzhou,Zhejiang,China

Science for Life Laboratory,KTH-Royal Institute of Technology,Stockholm,Sweden

Centre for Host-Microbiome Interactions,Faculty of Dentistry,Oral&Craniofacial Sciences,King's College London,London,UK

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Innovative Research Groups of the National Natural Science Foundation,China国家自然科学基金重大项目国家科技重大专项国家自然科学基金Zhejiang International Science and Technology Cooperation Project浙江省自然科学基金Zhejiang Medical AssociationInternational Youth Exchange Programme by China Association for Science and Technology(2019)Tianqing Liver Diseases Research FundMedical Health Science and Technology Project of Zhejiang Provincial Health Commis-sionOrgan Transplantation Overseas Training for Youth Talents from Shulan Excellent Talent ProjectCSCO(Chinese Society Of Clinical Oncology)-Bayer Tumor Research FundingOpen Fund of Key laboratory of High-Incidence-Tumor Prevention&Treat-ment(Guangxi Medical University)belonged to Ministry of Edu

81721091915422052017ZX 10203205819028132016C04003LY18H0300022019ZYC-A81TQGB202001142021KY145Y-bayer202001/zb-0003

2022

10.14218/JCTH.2021.00219

临床与转化肝病杂志(英文版)

临床与转化肝病杂志(英文版)

ISSN：
年,卷(期)：2022.10(2)
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