首页|Relationship between the Level of Serum Golgi Protein 73 and the Risk of Short-term Death in Patients with ALD-ACLF

Relationship between the Level of Serum Golgi Protein 73 and the Risk of Short-term Death in Patients with ALD-ACLF

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Background and Aims: As a hepatocellular carcinoma bio-marker, serum Golgi protein 73 (GP73) is reportedly related to inflammation. Acute-on-chronic liver failure (ACLF) is char-acterized by severe systemic inflammation. In this study, we aimed to explore the association between the GP73 level and short-term mortality in patients with alcohol-associated liver disease-related ACLF (ALD-ACLF). Methods: This retrospec-tive cohort study involved 126 Chinese adults with ALD-ACLF. Baseline serum GP73 level was measured using enzyme-linked immunosorbent assay. Patients were followed-up for 90 d and outcomes were assessed. Data were analyzed using multivariate Cox regression and piecewise linear regression analyses. The predictive value of GP73 and classic models for the short-term prognosis of participants were evaluated and compared using receiver operating characteristic curves. Re-sults: The serum GP73 level was independently associated with an increased mortality risk in patients with ALD-ACLF. Compared with the lowest tertile, the highest serum GP73 level predisposed patients with ALD-ACLF to a higher mortal-ity risk in the fully adjusted model [at 28 days: hazard ratio (HR): 4.29 (0.99–18.54), p=0.0511; at 90 days: HR: 3.52 (1.15–10.79), p=0.0276]. Further analysis revealed a posi-tive linear association. GP73 significantly improved the ac-curacy of the Child-Turcotte-Pugh score, model for end-stage liver disease score, and model for end-stage liver disease-sodium score in predicting short-time prognosis of patients with ALD-ACLF. Conclusions: The serum GP73 level is a sig-nificant predictor of the subsequent risk of death in patients with ALD-ACLF. GP73 improved the predictive value of classic prognostic scores.

Golgi protein 73 (GP73)Alcohol-associated liver diseaseAcute-on-chronic liver failure (ACLF)PrognosisRetrospective cohort study

Jingjing Tong、Mingjie Yao、Xiuying Mu、Leijie Wang、Xiajie Wen、Xingran Zhai、Xiang Xu、Yu Wang、Jing Chen、Xiangwei Zhai、Chongdan Guan、Fengmin Lu、Jinhua Hu

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Chinese PLA Medical School,Beijing,China

Senior Department of Hepatology,the Fifth Medical Center of PLA General Hospital,Beijing,China

Department of Anatomy and Embryology,School of Basic Medical Sciences,Peking University Health Science Center,Beijing,China

Peking University 302 Clinical Medical School,Beijing,China

Department of Mi-crobiology&Infectious Disease Center,School of Basic Medical Sciences,Peking University Health Science Center,Beijing,China

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Capital's Funds for Health Improvement and Research,China

2020-1-5031

2022

10.14218/JCTH.2020.00133

临床与转化肝病杂志(英文版)

临床与转化肝病杂志(英文版)

ISSN：
年,卷(期)：2022.10(3)
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