首页|Sex-specific Cutoff Values of Visceral Fat Area for Lean vs.Overweight/Obese Nonalcoholic Fatty Liver Disease in Asians

Sex-specific Cutoff Values of Visceral Fat Area for Lean vs.Overweight/Obese Nonalcoholic Fatty Liver Disease in Asians

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Background and Aims: Visceral obesity is a risk factor for nonalcoholic fatty liver disease (NAFLD). We investigated sex-specific optimal cutoff values for visceral fat area (VFA) associated with lean and overweight/obese NAFLD in an Asian population. Methods: This retrospective study includ-ed 678 potential living liver donors (mean age, 30.8±9.4 years; 434 men and 244 women) who had undergone ab-dominal computed tomography (CT) imaging and liver bi-opsy between November 2016 and October 2017. VFA was measured using single-slice abdominal CT. NAFLD was eval-uated by liver biopsy (≥5％ hepatic steatosis). Receiver op-erating characteristic curve analysis was used to determine cutoff values for VFA associated with lean (body mass index [BMI] <23 kg/m2) and overweight/obese (BMI ≥23 kg/m2) NAFLD. Results: Area under the curve (AUC) values with 95％ confidence intervals (CI) for VFA were 0.82 (95％ CI, 0.75–0.88) for lean and 0.74 (95％ CI, 0.69–0.79) for over-weight/obese men with NAFLD. The AUC values were 0.67 (95％ CI, 0.58–0.75) for lean and 0.71 (95％ CI, 0.62–0.80) for overweight/obese women with NAFLD. The cutoff values for VFA associated with lean NAFLD were 50.2 cm2 in men and 40.5 cm2 in women. The optimal cutoff values for VFA associated with overweight/obese NAFLD were 100.6 cm2 in men and 68.0 cm2 in women. Conclusions: Sex-specific cutoff values for VFA may be useful for identifying subjects at risk of lean and overweight/obese NAFLD.

Hepatic steatosisAdipose tissueLiver biopsyComputed tomog-raphy..

Sunyoung Lee、Kyoung Won Kim、Jeongjin Lee

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Department of Radiology and Research Institute of Radiological Science,Severance Hospital,Yonsei University College of Medicine,Seoul,Republic of Korea

Department of Radiology and Research Institute of Radiology,Asan Medical Center,University of Ulsan College of Medicine,Seoul,Republic of Korea

School of Computer Science and Engineering,Soongsil University,Seoul,Republic of Korea

2022

10.14218/JCTH.2021.00379

临床与转化肝病杂志(英文版)

临床与转化肝病杂志(英文版)

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年,卷(期)：2022.10(4)
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