首页|Liver Function Derangement in Patients with Severe Fever and Thrombocytopenia Syndrome

Liver Function Derangement in Patients with Severe Fever and Thrombocytopenia Syndrome

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Background and Aims: Patients with severe fever with thrombocytopenia syndrome (SFTS) commonly show liv-er function impairment. This study aimed to characterize the liver function indices in SFTS patients and investigate their association with mortality. Methods: Clinical infor-mation and laboratory results of 459 laboratory-confirmed SFTS patients, including 78 deceased and 381 surviving patients, were retrospectively analyzed. To explore the in-fectivity of SFTS caused by novel Bunyavirus (SFTSV) in hepatocytes, Huh7 human hepatoma cells were infected with various concentrations of SFTSV in vitro. Results: The proportion of SFTS patients developing liver injury during hospitalization was 73.2％ (336/459); the hepatocellular injury was the predominant type. The median time to oc-currence of liver injury from disease onset was 8 d. Liver injury in the deceased group occurred earlier than that in the surviving group. Alanine aminotransferase (ALT) level between 2–5 times upper limit of normal (ULN) at 4–6 d and between 5–15 ULN at 7–12 d of disease course were independent predictors of mortality. Alkaline phosphatase (ALP) >2 ULN at 7–9 d and elevated ALP at 10–12 days after disease onset were risk factors for death. ALT and aspartate transaminase (AST) levels were correlated with lymphocyte count and platelet-to-lymphocyte ratio (PLR). Total bilirubin (TB), ALT, AST levels showed positive cor-relation with viral load. In the in vitro experiment, SFTSV infected and replicated inside Huh7 cells. Conclusions: Liver injury is common in SFTS patients. ALT and ALP were independent predictors of SFTS-related mortality. Fre-quent monitoring and evaluation of liver function indices are needed for SFTS patients.

Severe Fever with Thrombocytopenia SyndromeLiver Function TestsMortalityRisk Factors

Sihong Lu、Ling Xu、Boyun Liang、Hua Wang、Tong Wang、Tiandan Xiang、Sumeng Li、Lei Fan、Junyuan Li、Cheng Peng、Xin Zheng

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Department of Infectious Diseases,Union Hospital,Tongji Medical College,Joint International Laboratory of Infection and Immunity,Huazhong University of Science and Technology,Wuhan,Hubei,China

Innovation Team Project of Health Commission of Hubei Province湖北省自然科学基金Sansheng Thrombocytopenia(TCP)Youth Research project国家科技重大专项国家科技重大专项国家科技重大专项国家重点研发计划中央高校基本科研业务费专项Ap-plied Basic and Frontier Technology Research Project of Wu-han

WJ2019C0032018CFB4712018ZX103022062018ZX107232032017ZX 10304402-002-0052017YFC09081042020kfyXGYJ0162020020601012233

2022

10.14218/JCTH.2021.00345

临床与转化肝病杂志(英文版)

临床与转化肝病杂志(英文版)

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年,卷(期)：2022.10(5)
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