Portal Hypertension in Nonalcoholic Fatty Liver Disease: From Pathogenesis to Clinical Practice

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外文摘要：Portal hypertension in nonalcoholic fatty liver disease (NAFLD) mostly occur in cirrhotic stage. However, several experimental and clinical studies showed evidence of portal hypertension in NAFLD without significant or advance fibrosis. This early de-velopment of portal hypertension in NAFLD is associated with liver sinusoidal contraction by hepatocellular lipid accumula-tion and ballooning, which is also accompanied by capillariza-tion and dysfunction of liver sinusoidal endothelial cells. Both of these impaired mechanical and molecular components can cause an increase in intrahepatic vascular resistance which lead to the increase of portal pressure in the absence of sig-nificant liver fibrosis. Extrahepatic factors such as insulin re-sistance and gut dysbiosis may also contribute to liver sinu-soidal endothelial dysfunction and early portal hypertension in NAFLD. The clinical impact of early portal hypertension in NAFLD is still unclear. However, clinical tools for diagnosis and monitoring of portal hypertension in NAFLD are being investi-gated to predict high-risk patients and to guide therapy.

外文关键词：

Portal hypertensionNAFLDNASHMetabolic

作者：

Saut Horas H.Nababan、Cosmas Rinaldi Adithya Lesmana

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作者单位：

Hepatobiliary Division,Department of Internal Medicine,Dr Cipto Mangunkusumo National General Hospital,Medical Fac-ulty Universitas Indonesia,Jakarta,Indonesia

Gastrointestinal Cancer Center,MRCCC Siloam Semanggi Hospital,Jakarta,Indonesia

Digestive Disease&GI Oncology Center,Medistra Hospital,Jakarta,Indonesia

出版年：

2022

DOI：

10.14218/JCTH.2021.00593

临床与转化肝病杂志(英文版)

ISSN：

年,卷(期)：2022.10(5)

参考文献量69