A survey of the real-world clinical application of TACE in the treatment of hepatocellular carcinoma in China
Objective Hepatocellular carcinoma(HCC),the most common type of primary liver cancer,makes up approximately 90%of liver cancer patients.China is a country with the highest incidence and death number of HCC in the world.Compared with European and American countries,patients with HCC in China are different in their etiology,epidemiological characteristics,clinical manifestation and stage,treatment strategy and prognosis.Transarterial chemoembolization(TACE),as an important interventional technique,plays a crucial role in the treatment of HCC.The objective of this study is to investigate and analyze the clinical characteristics,treatment pattern and outcomes of HCC patients treated with TACE in China.Methods Patients with HCC in the Chinese Primary Liver Cancer Clinical Registry Survey database who underwent at least one TACE from 2012 to 2019 were collected.We described the clinical characteristics and clinical treatment,and observed the survival status of the patients with TACE.Results A total of 5342 patients who underwent at least one TACE were analyzed.Median age at diagnosis was 56.9(range:18.6-92.1)years,and most(84.0%)were male.75.7%and 3.2%of HCC cases were attributable to hepatitis B virus(HBV)and hepatitis C virus(HCV)infections,respectively.Eastern Cooperative Oncology Group performance status(ECOG PS)0-1 accounted for 94.3%of the patients.Among the patients with clinical staging,31.9%were in Barcelona Clinic Liver Cancer(BCLC)stage 0-A,65.0%were in BCLC stage B-C,and 3.1%were in BCLC stage D.89.7%patients in all groups initially received TACE.The median follow-up period was 10.7 months.The 1-,3-and 5-year overall survival rates were 60.2%,35.1%and 25.6%,respectively.The BCLC stage was significantly associated with the survival of the patients treated with TACE(P<0.05).Conclusion Patients′characteristics and clinical stage might be further considered in the treatment of HCC with TACE for better treatment outcomes.
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