Analysis of the effect of peri-chemotherapy period on coagulation function before and after COVID-19 infection in patients with malignant tumors
Objective To retrospectively analyze the impact of chemotherapy before and after the infection with 2019-nCoV on coagulation indicators in patients with malignant tumors.Methods From October 2022 to April 2023,62 patients bearing malignant tumors treated before and after 2019-nCoV infection were enrolled in this study.The changes in blood routine and coagulation indicators before and after each cycle of chemotherapy before 2019-nCoV infection,before and after each cycle of chemotherapy after infection recovery,and one month after the end of the fourth cycle of chemotherapy were recorded.Results Compared with before the first cycle of chemotherapy,the ratio of neutrophil(NEU)to lymphocyte count(NLR)increased after chemotherapy,while lymphocytes(LYM)and platelets(PLT)decreased(P<0.05);Compared with before the second cycle of chemotherapy,NEU and NLR increased,while LYM and PLT decreased after chemotherapy(P<0.05).After rehabilitation from 2019-nCoV infection,there was no statistically significant difference in NEU,LYM,NLR,and PLT before the third cycle and after the fourth cycle of chemotherapy(P>0.05).After the rehabilitation of 2019-nCoV infection,NLR increased significantly before chemotherapy and one month after the fourth cycle of chemotherapy,while LYM and PLT were still lower than those before chemotherapy(P<0.05).Compared with before and after the first cycle of chemotherapy,the level of D-dimer increased(P<0.05).After recorery from 2019-nCoV infection,there was no statistically significant difference in prothrombin time(PT),activated partial thromboplastin time(APTT),fibrinogen(FIB),international normalized ratio(INR)and D-dimer between before the third cycle and after the fourth cycle of chemotherapy(P>0.05).There was no statistically significant difference in PT,APTT,FIB,INR and D-dimer before chemotherapy after rehabilitation and one month after the fourth cycle of chemotherapy(P>0.05).Conclusion After 2019-nCoV rehabilitation,chemotherapy does not have significant impact on coagulation function in malignant tumor patients in a hypercoagulable state.Effectively controlling the development of malignant tumors will not increase the risk of thrombosis.
Malignant tumor2019-noval coronavirusChemotherapyCoagulation function
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