Value of CST4 combined with CEA,CA72-4 and CA19-9 in the diagnosis and efficacy evaluation of gastric cancer
Objective To investigate the potential enhancement of diagnostic accuracy in gastric cancer through the combined detection of serum tumor markers(CST4,CEA,CA72-4,CA19-9).We also examined CST4 levels in both preoperative and postoperative gastric cancer patients to evaluate the correlation between CST4 levels and tumor burden.Methods Preoperative serum specimens were collected from 236 patients with gastric cancer,including 136 postoperative specimens,and 69 cases of healthy people.Serum level of CST4,CEA,CA72-4 and CA19-9 were detected by enzyme-linked immunosorbent assay(ELISA).Results The average preoperative contents of CST4,CEA,CA72-4 and CA19-9 in the gastric cancer group were 78.60 U/ml,2.35 ng/ml,2.96 U/ml and 9.25 U/ml,respectively,which were significantly higher than those in the control group with 46.77 U/ml,1.49 ng/ml,2.02 U/ml and 4.69 U/ml(all P<0.05).The positive rates of preoperative CST4,CEA,CA72-4 and CA19-9 in the gastric cancer group were 20.34%,20.76%,14.41%and 11.44%,respectively,significantly higher than those in healthy people with 7.25%,4.35%,4.35%and 1.45%(all P<0.05).ROC curves showed that the sensitivity for the combined detection of CST4 with CEA,CA72-4,and CA19-9 was 0.42,and the AUC was 0.74(95%CI:0.68-0.78),which were higher than the sensitivity and AUC of single detection.There was a significant difference in CST4 levels between gastric cancer patients before(47.82 U/ml)and after(26.65 U/ml)surgery(P<0.05).Conclusion The combined detection of CST4,CEA,CA72-4,CA19-9 can improve the diagnostic performance of gastric cancer,and has certain clinical value for the diagnosis and efficacy observation of gastric cancer.
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