宫颈癌组织中PD-L1/PD-L2的表达及临床意义
Expression and clinical significance of PD-L1/PD-L2 in cervical cancer tissues
王文芳 1侯岩峰 1程晓伟 1杨宇星 1郭春花 1汪美华 2邵莉萍1
作者信息
- 1. 213032 江苏常州 常州市肿瘤(第四人民)医院妇产科
- 2. 213032 常州市肿瘤(第四人民)医院病理科
- 折叠
摘要
目的 探讨宫颈癌组织中程序性死亡因子配体 1(PD-L1)和配体 2(PD-L2)的表达及临床意义.方法 采用免疫组化法检测78 例宫颈癌组织中PD-L1、PD-L2 的表达情况,分析PD-L1、PD-L2 表达和人乳头瘤病毒(HPV)感染与宫颈癌临床病理特征的关系.结果 78 例宫颈癌组织中,PD-L1 表达阳性 53 例、阴性 25 例,PD-L2 表达阳性 48 例、阴性 30 例,PD-L1、PD-L2 阳性表达率分别为 67.95%和 61.54%.HPV感染与宫颈癌组织PD-L1 表达和肿瘤大小无关(P>0.05),而与PD-L2 表达、FIGO分期和淋巴结浸润有关(P<0.05).PD-L1 表达与宫颈癌的FIGO分期有关(P<0.05),而与肿瘤大小和淋巴结浸润无关(P>0.05);PD-L2 表达与宫颈癌的FIGO分期、肿瘤大小和淋巴结浸润均无关(P>0.05).PD-L1 阳性组织肿瘤比例评分与淋巴结浸润有关(P<0.05),而与FIGO分期、肿瘤大小和HPV感染无关(P>0.05).结论 PD-L1 表达可作为宫颈癌的生物标志物来评价宫颈癌的恶性程度,PD-L2 表达与HPV感染关系密切,为基于PD-1/PD-L1/2 信号通路的靶向治疗提供了临床依据.
Abstract
Objective To explore the expression and clinical significance of programmed death ligand-1(PD-L1)and programmed death ligand-2(PD-L2)in cervical cancer tissues.Methods Immunohistochemical method was used to detect the expression of PD-L1 and PD-L2 in 78 cervical cancer tissues.Then,we analyzed the relationships of PD-L1,PD-L2 expression and human papillomavirus(HPV)infection with clinical pathological characteristics of cervical cancer.Results Among 78 cervical cancer tissues,there were 53 positive and 25 negative cases of PD-L1 expression,48 positive and 30 negative cases of PD-L2 expression.The positive expression rates of PD-L1 and PD-L2 were 67.95%and 61.54%,respectively.HPV infection was not associated with PD-L1 expression and tumor size in cervical cancer(P>0.05),but was associated with PD-L2 expression,FIGO staging and lymph node metastasis(P<0.05).PD-L1 expression was associated with FIGO staging of cervical cancer(P<0.05),but not with tumor size and lymph node infiltration(P>0.05).PD-L2 expression was not related to FIGO staging,tumor size and lymph node infiltration of cervical cancer(P>0.05).The tumor proportion score of PD-L1 positive tissues was associated with lymph node infiltration(P<0.05),but not with FIGO staging,tumor size and HPV infection(P>0.05).Conclusion PD-L1 expression can serve as a biomarker for evaluating the malignancy of cervical cancer,and PD-L2 expression is closely related to HPV infection,providing clinical evidence for targeted therapy based on the PD-1/PD-L1/2 pathway.
关键词
宫颈癌/程序性死亡因子配体1/程序性死亡因子配体2/人乳头瘤病毒感染Key words
Cervical cancer/Programmed death ligand-1/Programmed death ligand-2/Human papillomavirus infec-tion引用本文复制引用
基金项目
江苏省中药药效与安全性评价重点实验室项目(JKLPSE201908)
出版年
2024
NETL
NSTL
万方数据