Expression and clinical significance of PD-L1/PD-L2 in cervical cancer tissues
Objective To explore the expression and clinical significance of programmed death ligand-1(PD-L1)and programmed death ligand-2(PD-L2)in cervical cancer tissues.Methods Immunohistochemical method was used to detect the expression of PD-L1 and PD-L2 in 78 cervical cancer tissues.Then,we analyzed the relationships of PD-L1,PD-L2 expression and human papillomavirus(HPV)infection with clinical pathological characteristics of cervical cancer.Results Among 78 cervical cancer tissues,there were 53 positive and 25 negative cases of PD-L1 expression,48 positive and 30 negative cases of PD-L2 expression.The positive expression rates of PD-L1 and PD-L2 were 67.95%and 61.54%,respectively.HPV infection was not associated with PD-L1 expression and tumor size in cervical cancer(P>0.05),but was associated with PD-L2 expression,FIGO staging and lymph node metastasis(P<0.05).PD-L1 expression was associated with FIGO staging of cervical cancer(P<0.05),but not with tumor size and lymph node infiltration(P>0.05).PD-L2 expression was not related to FIGO staging,tumor size and lymph node infiltration of cervical cancer(P>0.05).The tumor proportion score of PD-L1 positive tissues was associated with lymph node infiltration(P<0.05),but not with FIGO staging,tumor size and HPV infection(P>0.05).Conclusion PD-L1 expression can serve as a biomarker for evaluating the malignancy of cervical cancer,and PD-L2 expression is closely related to HPV infection,providing clinical evidence for targeted therapy based on the PD-1/PD-L1/2 pathway.
Cervical cancerProgrammed death ligand-1Programmed death ligand-2Human papillomavirus infec-tion
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