Clinicopathological analysis of 11 cases of solitary fibrous tumor
Objective Objective To investigate the clinicopathology,immunophenotype and prognosis of solitary fibrous tumor(SFT).Methods The clinical and pathological data of 11 patients with SFT were collected.HE and immunohistochemical staining were performed,the clinical and imaging manifestations,histological morphology,immunophenotypic characteristics,and prognosis were summarized,and the relevant literatures were reviewed.Results There were 11 cases of SFT,including 9 males and 2 females.The range of onset age was 25-85.Imaging findings all present as nodular soft tissue masses.Gross observation showed that the maximum diameter of the tumor was 3.5-30 cm.The section was solid with or without complete capsule.The tumor cells was typically oval,spindle or fusiform.The cell density varied from sparse to dense with characteristic staghorn-like vessels.In some cases,the tumor cells have mild-to-moderate atypia with occasionally bizarre morphology.All tumors cells was CD34 positive,and STAT6 was positive in 8 cases.Surgical complete resection was still the first treatment method for SFT.Among the 10 patients in this group who received follow-up result,8 survived disease-free,1 died due to unknown causes,and 1 survived with tumor after surgery.Conclusion SFT has a relatively unique histological morphology and molecular genetic changes.Extrapleural SFT has more invasive biological behavior.Patients with malignant histological features were directly diagnosed as malignant SFT,with a high rate of local recurrence and metastasis.Therefore,correct diagnosis is of great significance for treatment and clinical management.
NETL
NSTL
万方数据
