The clinical significance of F-NLR score in evaluating the efficacy of patients with advanced non-small cell lung cancer
Objective To investigate the efficacy and prognosis of F-NLR score in advanced non-small cell lung cancer.Methods Seventy-two patients with advanced non-small cell lung cancer from March 2018 to April 2019 were selected as the observation group,and the patients were taken 6 consecutive cycles of chemotherapy.According to the treatment response,they were divided into chemotherapy insensitive group(recurrence or metastasis)and chemotherapy sensitive group.Forty-nine healthy subjects were selected as control group.Fibrinogen(FIB)level was detected by automatic coagulation analyzer.Neutrophil count and lymphocyte count were detected by automatic cell analyzer,and NLR was calculated.The receiver operating characteristic(ROC)curve was used to determine the FIB and NLR thresholds and then the F-NLR score was calculated.The relationship between F-NLR score and clinicopathological features of patients with non-small cell lung cancer was analyzed.Cox proportional regression model was used to analyze the factors affecting 3-year overall survival of patients.Results ROC curve showed that when FIB level was 3.43 g/L and NLR was 2.52,the curative effect of advanced non-small cell lung cancer patients could be predicted(P<0.05).The FIB,NLR and F-NLR scores of advanced non-small cell lung cancer patients in observation group were higher than those in control group,and the differences were statistically significant(P<0.05).FIB,NLR and F-NLR scores in chemotherapy insensitive group were higher than those in chemotherapy sensitive group,and the differences were statistically significant(P<0.05).F-NLR score was correlated with differentiation degree and lymph node metastasis(P<0.05).Cox proportional regression model analysis showed that differentiation degree,lymph node metastasis and F-NLR score were the influencing factors for 3-year OS in advanced non-small cell lung cancer patients(P<0.05).Conclusion High F-NLR score is associated with poor chemotherapy response and prognosis of advanced non-small cell lung cancer patients,and may be a predictor of treatment response and poor prognosis of patients.
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