Expression and clinical significance of CXCL10 and CXCL16 in gliomas based on bioinformatics analysis
Objective To investigate the potential of CXC chemokine ligand 10(CXCL10)and CXC chemokine ligand 16(CXCL16)as prognostic markers in glioma by bioinformatics.Methods GSE15824 and GSE16011 datasets were obtained from the GEO database to identify differences in the expression of CXCL10 and CXCL16 between glioma and non-tumor tissues.The clinical data of The Cancer Genome Atlas(TCGA)and Chinese Glioma Genome Atlas(CGGA)were analyzed,retrospectively.The functional enrichment analysis of CXCL10 and CXCL16 was performed using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes.Results CXCL10 and CXCL16 were highly expressed in glioma.The higher the expression of CXCL10 and CXCL16,the worse the prognosis.Both of them had certain diagnostic value in predicting 1,3,5-year survival rate of patients.Functional enrichment analysis showed that CXCL10 and CXCL16 played a major role in immunological function.Conclusion Bioinformatic analysis indicates that CXCL10 and CXCL16 are potential diagnostic and prognostic biomarkers in gliomas and may serve as novel targets for glioma treatment.
万方数据
维普
