Prognostic value of tissue RP11-388M20.1 level in patients with gastric cancer undergoing radical gastrectomy
Objective To investigate the level of long non-coding RNA RP11-388M20.1 in gastric cancer tissues and its value in evaluating the prognosis of patients undergoing radical gastrectomy.Methods One hundred and three patients who underwent radical gastrectomy for gastric cancer in our hospital from January 2018 to December 2020 were selected.Rea-time quantitative PCR was used to detect the differential expression of RP11-388M20.1 between gastric cancer tissues and corresponding adjacent tissues.Relationship of RP11-388M20.1 level with clinical pathological characteristics of gastric cancer patients were analyzed.Kaplan-Meier survival curve and Cox proportional risk model were applied to analyze the value of RP11-388M20.1 in predicting the prognosis of gastric cancer patients undergoing radical surgery.Results The RP11-388M20.1 level in 103 gastric cancer tissues was 5.013±0.184,higher than the 1.471±0.056 in adjacent tissues(t=18.399,P＜0.001).The expression of RP11-388M20.1 in gastric cancer tissues was significantly associated with TNM staging(P=0.005),tumor size(P=0.038),differentiation degree(P=0.002),T staging(P=0.029),and carcinoembryonic antigen status(P=0.022).Results of univariate analysis showed that the expression of RP11-388M20.1 was related to the prognosis of gastric cancer.Among them,the median disease-free survival of patients with low expression of RP11-388M20.1 was unreached,better than 36 months of those with high expression(HR=2.936,95%CI:1.808-4.768,P＜0.001);Multivariate analysis showed that high expression of RP11-388M20.1 was a risk factor for poor prognosis in gastric cancer(HR=2.076,95%CI:1.070-4.026,P=0.031).Conclusion RP11-388M20.1 is an overexpressed long non-coding RNA in gastric cancer tissues,which is associated with gastric cancer progression and poor prognosis,and has the potential to serve as a diagnostic and therapeutic target for gastric cancer.
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