Relationship of GIPR expression with clinicopathological features and immune infiltration in gastric cancer tissues
Objective To explore the relationship of glucose-dependent insulinotropic polypeptide receptor(GIPR)expression with clinicopathological features and immune infiltration in gastric cancer tissues.Methods Sixty-one gastric cancer patients who underwent surgery in our hospital from March 2017 to April 2018 were collected.GIPR expression in gastric cancer tissues was detected by real-time quantitative PCR.Clinical pathological data and follow-up data were combined to analyze the clinical significance of GIPR expression in gastric cancer.Tumor immune estimation resources(TIMER)were used to evaluate the association between GIPR expression and immune cell infiltration.Results Compared with normal tissues adjacent to cancer,the expression of GIPR in gastric cancer tissues was significantly increased,and the expression of GIPR in gastric cancer tissues was related to tumor size,TNM stage,and lymph node metastasis(P＜0.05).The median disease-free survival of patients with high expression of GIPR was 43.0(95%CI:37.0-45.5)months,which was lower than the 52.0(95%CI:49.5-60.0)months of the low expression individuals(HR=2.625,95%CI:1.965-4.652,P=0.004).Multivariate analysis showed that high expression of GIPR was an independent factor for poor prognosis in gastric cancer patients(HR=2.522,95%CI:1.530-4.157,P=0.009).The TIMER database analysis results showed that GIPR was positively correlated with B cell infiltration levels in gastric cancer(r=0.172,P＜0.001),but not with immune infiltration levels of CD8+T cells(r=-0.003,P=0.949),CD4+T cells(r=0.062,P=0.234),macrophages(r=-0.019,P=0.711),neutrophils(r=0.034,P=0.515),and dendritic cells(r=0.043,P=0.406).Conclusion GIPR is abnormally highly expressed in gastric cancer tissue and is associated with poor prognosis and B cell infiltration,participating in the malignant progression of gastric cancer.
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