Expression of BARD1 in esophageal squamous carcinoma tissues and its correlation with lymph node metastasis
Objective To analyze the expression of breast cancer susceptibility gene 1-associated ring structural domain protein 1(BARD1)in esophageal squamous cell carcinoma(ESCC)tissues and its correlation with lymph node metastasis.Methods From January 2018 to December 2021,114 patients with ESCC diagnosed by histopathological examination in our hospital were included.Immunohistochemical EnVision two-step method was used to detect the BARD1 expression in cancer tissues and adjacent tissues,and then positive rates of BARD1 were compared.Relationship between the BARD1 expression and the clinicopathological features of ESCC was evaluated.Logistic regression model was established to analyze the influence of BARD1 expression on lymph node metastasis of ESCC,and receiver operating characteristic(ROC)curve was used to determine the predictive value of BARD1 expression on lymph node metastasis of ESCC.Results Among 114 ESCC tissues,78 were positive and 36 were negative for BARD1,corresponding to 23 positive and 91 negative for BARD1 in adjacent cancerous tissues.The positive rate of BARD1 in ESCC tissues was 68.42%,higher than the 20.18%in adjacent tissues(χ2=53.769,P＜0.001).BARD1 expression was related to T stage,differentiation degree,and lymph node metastasis in ESCC patients(P＜0.05),with a positive rate of BARD1 in lymph node metastasis tissues of 80.36%(45/56),higher than 56.90%(33/58)in non-metastatic tissues.Through Phi coefficient analysis,it was found that BARD1 expression was positively correlated with lymph node metastasis in ESCC(r=0.276,P=0.003).BARD1 positivity was an independent risk factor for lymph node metastasis in ESCC patients(OR=3.099,95%CI:1.339-7.175,P=0.008),and BARD1 expression had certain predictive value for lymph node metastasis in ESCC patients(AUC=0.636,P=0.020).Conclusion BARD1 is highly expressed in ESCC and is closely related to lymph node metastasis in ESCC.Positive BARD1 increases the risk of lymph node metastasis and has certain value in evaluating lymph node metastasis in ESCC.
Esophageal squamous cell carcinomaRing-domain protein 1 associated with breast cancer susceptibility gene 1Lymph node metastasisClinical significance
万方数据
维普
