Objective To explore the expression and prognostic significance of glutaredoxin(GLRX)in cervical cancer tissues.Methods Real-time quantitative PCR was used to detect the expression level of GLRX in 120 cases of cervical cancer tissues and normal adjacent tissues.Relationship of GLRX levels in tissues with clinicopathological characteristics and prognosis of cervical cancer patients were analyzed in a hierarchical manner,and Cox proportional risk model was employed for risk factor analysis.Results The expression level of GLRX in cervical cancer tissues was 2.44±0.86,higher than 1.00±0.65 in normal adjacent tissues(P＜0.05).The area under the curve for predicting the occurrence of cervical cancer based on the expression level of GLRX in tissues was 0.853(95%CI:0.788-0.919).GLRX expression in cervical cancer patients was correlated with FIGO stage,lymph node metastasis,tumor infiltration and maximum tumor diameter(P＜0.05).Univariate analysis showed that GLRX expression was associated with overall survival(OS)in cervical cancer,with the median OS not reached in the low expression group,which was better than 40.0 months in the high expression group(P＜0.05).Multivariate analysis showed that low expression of GLRX was an independent protective factor affecting the prognosis of cervical cancer patients(HR=0.215,95%CI:0.095-0.486,P＜0.001).Conclusion GLRX overexpression can serve as a potential molecular marker for the diagnosis and prognosis of cervical cancer patients.
万方数据
维普
