Expression and clinical significance of Engrailed-1 in gastric cancer
Objective To investigate the expression and clinical significance of Engrailed-1(EN1)transcription factor in the tissues of primary gastric cancer and lymph node metastases.Methods The expression of EN1 in 99 gastric cancer tissues and 15 lymph node metastases was detected by immunohistochemical method.The relationship between abnormal expression,prognosis and clinicopathological parameters was analyzed.Kaplan-Meier method and Log-rank test were used for survival analysis.Cox proportional regression model was used for multivariate analysis.Results The high expression rate of EN1 in primary gastric cancer was 57.6％(57/99).The expression of EN1 in primary gastric cancer tissues was correlated with the depth of invasion(P＜0.05),but not with age,sex,nerve invasion,depth of invasion,tissue differentiation and TNM stage(P＞0.05).Kaplan-Meier survival analysis showed that the median overall survival time of EN1 high-expression patients was 20.1 months,which was significantly lower than that of low-expression patients(unachieved)with statistical differences(P＜0.001).Multivariate analysis showed that age,depth of invasion,nerve invasion,tissue differentiation and EN 1 were independent prognostic factors for gastric cancer patients(P＜0.05).The expression intensity of EN1 in lymph node metastasis was significantly higher than that in primary lymph node metastasis(P＜0.05).Conclusion EN1 is high-expressed in primary and lymph node metastases of gastric cancer,and is associated with prognosis,suggesting that EN1 is involved in the occurrence and development of gastric cancer,and may be a potential biomarker for predicting the outcome of patients with gastric cancer.
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