Changes of serum squamous cell carcinoma antigen and matrix metalloproteinase level in patients with locally advanced lung cancer after simultaneous intensive modulated radiotherapy and their clinical significance
Objective To investigate the level of serum squamous cell carcinoma antigen(SCC-Ag)and metalloproteinase in patients with locally advanced lung cancer after simultaneous intensive modulated radiotherapy(SIB-IMRT)clinical significance.Methods The chinical data of 148 patients with primary lung cancer was colledcted from April 2018 to March 2021 in the Peace Hospital Affiliated to Changzhi Medical College.Serum levels of SCC-Ag,MMP-2 and MMP-9 were measured by ELISA in 148 patients at admission and one month after radiotherapy.Overall survival(OS),progression-free survival(PFS),toxicity and total response rate(ORR)were followed up.Results The efficacy of all patients was evaluated,with 16 cases achieving complete remission(CR),63 cases partial remission(PR),57 cases disease stability(SD),12 cases disease progression(PD),and an ORR of 53.38％(79/148).Acute radiation esophagitis occurred in 110 patients,27 of whom were grade 3.Acute radiation-induced pneumonia occurred in 39 patients,14 of whom had acute radiation-induced pneumonia before radiotherapy.Serum SCC-Ag levels in the effective group(CR+PR)were slightly lower than those in the ineffective group(SD+PD),and the difference was statistically significant(P=0.037).After one month of radiotherapy,serum SCC-Ag,MMP-2 and MMP-9 levels in both groups decreased(P＜0.05),but the decrease was more significant in the effective group(P＜0.001).Multivariate Cox analysis showed that the level of SCC-Ag before radiotherapy was an independent predictor of OS and PFS,and the level of SCC-Ag and MMP-9 after radiotherapy were independent predictors of OS.The median OS in patients with SCC-Ag levels＜7.60 μg/L before radiotherapy was longer than that in patients with SCC-Ag≥7.60 μg/L before radiotherapy.The median PFS of patients with SCC-Ag levels＜1.40 μg/L after radiotherapy was longer than that of patients with SCC-Ag levels ≥1.40 μg/L before radiotherapy.The median OS in patients with MMP-2 level＜23.81 μg/L after radiotherapy was longer than that in patients with MMP-2 level ≥23.81 μg/L after radiotherapy.The median OS of patients with MMP-9 level＜74.70 μg/L after radiotherapy was longer than that of patients with MMP-9 level ≥74.70 μg/L.Conclusion Serum SCC-Ag,MMP-2 and MMP-9 may have a certain predictive value for the prognosis of lung cancer patients after radiotherapy,especially the SCC-Ag level before radiotherapy.
万方数据
维普
