Observation of coagulation status and analysis of influencing factors in patients with ovarian cancer undergoing chemotherapy
Objective To observe the blood coagulation state of patients with ovarian cancer undergoing chemotherapy and explore its influencing factors.Methods The clinical data of 105 patients with ovarian cancer treated in Beijing Obstetrics and Gynecology Hospital from February 2018 to January 2022 were analyzed retrospectively.The patients were divided into hypercoagulable group and non-hypercoagulable group according to the existence of hypercoagulable state after chemotherapy.The incidence and influencing factors of hypercoagulable state were explored.Results Of the 105 patients in this study,48 developed post-chemotherapy hypercoagulable status,with an incidence rate of 45.7％(48/105).Two of the coagulation markers were elevated by 64.6％(31/48),three by 33.3％(16/48),and four by 2.1％(1/48).Univariate analysis showed age,body mass index,number of chronic medical comorbidities,carbohydrate antigen 125(CA125)level after chemotherapy,leukocyte level after chemotherapy and tumor stage were potential influencing factors for the hypercoagulable state of ovarian cancer after chemotherapy(P＜0.05).Multivariate Logistic regression analysis showed that the number of chronic medical comorbidities and the level of CA125 after chemotherapy were independent influencing factors of hypercoagulable state after chemotherapy for ovarian cancer,and the OR values were 7.152(95％CI:1.991-25.695,P=0.003),1.005(95％CI:1.001-1.009,P=0.018).Conclusion Hypercoagulable state is common in patients with ovarian cancer undergoing chemotherapy.Attention should be paid to patients with multiple chronic medical comorbidities and high CA125 level after chemotherapy,and relevant prevention and treatment measures should be actively carried out.
万方数据
维普
