Objective To investigate the risk factors and prevention strategies for chronic pain after thoracoscopic lobectomy in patients with early non-small cell lung cancer(NSCLC).Methods The clinical data of 150 early-stage NSCLC patients who treated with thoracoscopic lobectomy in the Affiliated Hospital of Chifeng University from January 2019 to May 2023 was analyzed retrospectively.According to the incidence of postoperative chronic pain,they were divided into occurring group(41 cases)and non-occurring group(109 cases)respectively.The influencing factors of chronic pain after thoracoscopic lobectomy in early NSCLC patients were investigated using Logistic regression analysis.Results There were significant differences between the occurrence group and the non-occurrence group in terms of whether there was anxiety,whether there was diabetes,whether there was preoperative chest and back pain,morphine equivalent consumption for postoperative analgesia,drainage tube placement time and hospital stay(P<0.05).Multivariate Logistic regression analysis showed that anxiety,diabetes,preoperative chest and back pain,more morphine equivalent for postoperative analgesia,long drainage tube placement time,and long hospital stay were independent risk factors for chronic pain after thoracoscopic lobectomy in patients with early NSCLC(P<0.05).Conclusion Chronic pain after thoracoscopic lobectomy for early NSCLC were closely related to anxiety,diabetes,preoperative chest and back pain,more morphine equivalent for postoperative analgesia,long drainage tube placement time,and long hospital stay.Clinically,targeted prevention strategies can be given to patients to reduce the risk of postoperative chronic pain.