Radiotherapy combined with immunotherapy is one of the most promising tumour treatments available.Particle beams(protons and heavy ions),as an emerging oncological treatment,are mainly used to more effectively induce tumour cell apoptosis by enhancing the efficacy of immunotherapy.However,preclinical and clinical studies suggest that the underlying immunosuppressive mechanisms associated with conventional radiotherapy may limit its immunological potential.The dosimetric and biological differences exhibited by proton heavy ions as charged particles in normal and tumour cells could not only enhance the immunoadjuvant effect of radiotherapy,but also reduce the immunosuppressive mechanisms.Therefore,theoretically,the efficacy of particle-beam combined immunotherapy is not inferior to that of conventional radiotherapy combined with immunotherapy,but it is not widely used in the clinic at present.This paper reviews the research progress on the anti-tumour effect of conventional radiotherapy or particle-beam combined immunotherapy and its mechanism.
万方数据
维普
