肝癌组织中TRPML1和TRPML2表达及临床意义
Expression and clinical significance of TRPML1 and TRPML2 in hepatocellular carcinoma tissue
杨兴胜 1黄寅鹏 1智永杰 1李世正 2高子娱 3王亮1
作者信息
- 1. 121000 辽宁锦州 锦州医科大学附属第一医院肝胆外科
- 2. 121000 锦州医科大学附属第一医院急诊外科
- 3. 121000 锦州医科大学附属第一医院病理科
- 折叠
摘要
目的 探讨TRPML1 和TRPML2 在肝癌组织中的表达及临床意义.方法 选取锦州医科大学附属第一医院 2019 年 1 月至 2020 年 10 月收治的 90 例原发性肝癌患者,并收集肝癌组织及癌旁组织样本.免疫组化染色法检测TRPML1 和TRPML2 表达,分析TRPML1 和TRPML2 表达与临床病理特征和预后的关系.多因素Cox风险比例回归模型分析影响肝癌预后的因素.结果 肝癌组织中TRPML1 阳性率为 71.1%(64/90),显著高于癌旁组织的 30.0%(27/90),差异有统计学意义(P＜0.05);TRPML2 的阳性率为65.6%(59/90),显著高于癌旁组织的32.2%(29/90),差异有统计学意义(P＜0.05);TRPML1、TRPML2 表达与分化程度、TNM分期和浸润深度有关(均P＜0.05).Kaplan-Meier分析显示,TRPML1 和TRPML2 阳性表达患者的中位OS均显著少于阴性表达患者(P＜0.05).Cox回归分析显示,TRPML1 阳性表达和TRPML2 阳性表达可作为判断肝癌患者不良预后的独立因素(P＜0.05).结论 TRPML1 和TRPML2 在肝癌组织中的表达显著升高,TRPML1 和TR-PML2 阳性表达可作为评估肝癌患者不良预后的独立因子.
Abstract
Objective To investigate the expression and clinical significance of TRPML1 and TRPML2 in hepatocellular cancer.Methods Ninety patients with primary hepatocellular cancer admitted to our hospital from January 2019 to October 2020 were selected,and liver cancer tissue and para-cancer tissue samples were collected.The expression of TRPML1 and TRPML2 was detected by immunohistochemical staining,and the relationship between TRPML1 and TRPML2 expression and clinicopathological features and prognosis was analyzed.Multivariate Cox proportional regression model was used to analyze the prognostic factors of liver cancer.Results The positive rate of TRPML1 in liver cancer tissues was 71.1%(64/90),significantly higher than that in para-cancer tissues(30.0%,27/90).The positive rate of TRPML2 was 65.6%(59/90),which was significantly higher than 32.2%(29/90)in para-cancerous tissues.The expressions of TRPML1 and TRPML2 were correlated with the degree of differentiation,TNM stage and infiltration depth(P＜0.05).Kaplan-Meier analysis showed that the median OS of patients with positive expression of TRPML1 and TRPML2 was significantly lower than those with negative expression(P＜0.05).Cox regression analysis showed that the positive expression of TRPML1 and TRPML2 could be used as independent factors to judge the poor prognosis of patients with HCC(P＜0.05).Conclusion The expression of TRPML1 and TRPML2 in liver cancer tissues is significantly increased,and the positive expression of TRPML1 and TRPML2 can be used as independent factors to evaluate the poor prognosis of patients with hepatocellular cancer.
关键词
肝癌/TRPML1/TRPML2/预后Key words
Hepatocellular carcinoma/TRPML1/TRPML2/Prognosis引用本文复制引用
基金项目
辽宁省科学技术计划资助项目(2020-MS-297)
出版年
2024
NETL
NSTL
万方数据