The predictive value of serum exosome SUMO1P3 and MALAT1 for postoperative recurrence and metastasis in patients with triple-negative breast cancer
Objective To investigate the predictive value of serum exosome small ubiquitin-like modifier-1 pseudogene 3(SUMO1P3)and metastasis associated lung adenocarcinoma transcript 1(MALAT1)in postoperative recurrence and metastasis in patients with triple-negative breast cancer(TNBC).Methods A total of 224 patients with TNBC who underwent surgical resection from 2016 to 2020 were selected as the study subjects.According to the recurrence and metastasis during the follow-up period,they were divided into non-recurrence metastasis group and recurrence metastasis group.Clinical medical records of the two groups were collected.Real-time quantitative fluorescent PCR(qPCR)was used to detect the expression of serum exosomes SUMO1P3 and MALAT1 before surgery,and receiver operating characteristic(ROC)curve was drawn to evaluate the predictive value of SUMO1P3 and MALAT1 in postoperative recurrence and metastasis of TNBC.Multivariate Logistic regression model was used to analyze the factors affecting recurrence and metastasis after TNBC.Results A total of 72 patients had recurrence or metastasis.The relative expression levels of SUMO1P3 and MALAT1 in 224 TNBC patients were 3.06±0.68 and 2.75±0.66,respectively,among which the relative expression levels of SUMO1P3 and MALAT1 in the relapsed and metastatic group were 3.44±0.67 and 3.46±0.80,respectively.They were significantly higher than 2.88±0.61(P＜0.001)and 2.33±0.48(P＜0.001)in the non-recurrent metastasis group.ROC curve results showed that AUC of serum exosome SUMO1P3 and MALAT1 combined detection was 0.842(95%CI:0.787-0.887),the specificity was 0.790,the sensitivity was 0.806,and the combined prediction efficiency of the two indexes was better than that of SUMO1P3 and MALAT1 alone(P＜0.05).Multivariate Logistic regression model showed that SUMO1P3(OR=4.463,95%CI:2.125-9.372)and MALAT1(OR=9.103,95%CI:4.462-18.573)expression was an independent factor affecting the recurrence and metastasis after TNBC(P＜0.05).Conclusion Serum exosomes SUMO1P3 and MALAT1 are closely related to the prognosis of TNBC patients,and the combined detection of the two indicators has a high predictive value for postoperative recurrence or metastasis of TNBC.
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