Clinical significance of plasma dipeptidyl peptidase-4 level in medullary thyroid carcinoma
Objective To investigate the relationship between plasma dipeptidyl peptidase-4(DPP4)and disease-free survival(DFS),overall survival(OS)and biochemical cure after surgery for medullary thyroid carcinoma(MTC).Methods One hundred and forty-four MTC patients in our hospital from 2012 to 2022 were collected.Plasma DPP4 levels were determined by ELISA,and the relationship between plasma DPP4 levels and clinicopathological features and prognosis of MTC was analyzed.Results The plasma DPP4 level in the MTC survival group(n=131 cases)was significantly lower than that in the death group(n=12 cases),and the plasma DPP4 level in the non-recurrence group(n=120 cases)was significantly lower than that in the recurrence group(n=23 cases),with statistical significance(P＜0.001).Plasma DPP4 levels were correlated with sex,number of tumors,total number of lymph nodes dissected,number of metastatic lymph nodes,extrathyroid dilatation,pathological T stage,pathological N stage,survival and recurrence(P＜0.05).Kaplan-Meier results showed that the postoperative OS and DFS of MTC patients in the plasma DPP4≥0.12 ng/L group were lower(P＜0.05).The proportion of plasma DPP4≥0.12 ng/L was higher in patients without biochemical cure than in patients with biochemical cure(P＜0.001).Conclusion Preoperative elevated plasma DPP4 level is associated with poor prognosis in MTC patients and has the potential to be a prognosis biomarker of low invasive.
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