摘要
胃癌(Gastric cancer,GC)是消化系统最常见的恶性肿瘤之一,在我国发病率与死亡率均居恶性肿瘤前列.利用胃蛋白酶原、胃泌素、幽门螺杆抗体等血清学标志物对胃癌进行早期筛查的方法也被广泛应用于临床.近年来研究发现胃蛋白酶原和胃泌素可能通过促进胃癌细胞增殖、抑制肿瘤细胞凋亡等一系列途径来引导胃癌的发生发展而再度被重视,本文就目前胃蛋白酶原、胃泌素在胃癌发生发展中的作用作一综述.
Abstract
Gastric cancer(GC)is one of the most common malignant tumors of the digestive system,and its morbidity and mortality rank at the forefront of malignant tumors in China.Among them,the use of pepsinogen,gastrin,Helicobacter pylori antibody,and other serological markers for early screening of gastric cancer is also widely used in clinical practice.In recent years,it has been found that pepsinogen and gastrin may guide the occurrence and development of gastric cancer through a series of ways such as promoting cell proliferation and inhibiting cell apoptosis.This article reviews the current role of pepsinogen and gastrin in the occurrence and development of gastric cancer.Gastric cancer is one of the most common malignant tumors of the digestive system,and its morbidity and mortality rank at the forefront of malignant tumors in China.Among them,the use of pepsinogen,gastrin,Helicobacter pylori antibody,and other serological markers for early screening of gastric cancer is also widely used in clinical practice.In recent years,it has been found that pepsinogen and gastrin may guide the occurrence and development of gastric cancer through a series of ways such as promoting cell proliferation and inhibiting cell apoptosis.This article reviews the current role of pepsinogen and gastrin in the occurrence and development of gastric cancer.
基金项目
国家自然科学基金青年科学基金资助项目(31700792)
江苏省妇幼保健协会科研课题资助项目(FYX202017)
常州市科技计划资助项目(CE20225039)
安康市科学技术研究发展计划资助项目(AK2022-SF-07)
NETL
NSTL
万方数据