Clinical application value of serum Golgi glycoprotein 73 and phosphoglycerate kinase 1 combined with dynamic enhanced magnetic resonance scanning parameters in prostate cancer
Objective To explore the correlation of serum Golgi glycoprotein 73(GP73),phosphoglycerate kinase 1(PGK-1)and dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)parameters with pathological features and prognostic value of prostate cancer.Methods Seventy-eight patients with prostate cancer treated in our hospital from March 2018 to March 2022 were selected to be included in the study group,and 50 patients with benign prostatic hyperplasia treated in our hospital were selected to be included in the control group.The DCE-MRI parameters including volume transfer coefficient(Ktrans),reverse reflux rate constant(Kep),extracellular extravascular volume fraction(Ve)and serum GP73 and PGK-1 levels of the two groups were compared.The diagnostic and prognostic value for prostate cancer of the above indices were investigated.Results Compared with the control group,levels of GP73,PGK-1,Kep,and Ktrans in the study group increased before treatment(P＜0.05).Receiver operating characteristic(ROC)curve analysis showed that GP73,PGK-1,Kep,Ktrans,and their combination had high diagnostic value for prostate cancer before treatment.The area under the curve(AUC)values were 0.846,0.865,0.725,and 0.819,respectively,and the AUC value for combined diagnosis was 0.945.After treatment,the levels of GP73,PGK-1,and Kep in the study group were lower than those before treatment,while the levels of Ktrans and Ve were higher than those before treatment(P＜0.05).Levels of GP73,PGK-1,Kep,Ktrans,and Ve in the group with poor prognosis after treatment were higher than those in the group with good prognosis(P＜0.05).ROC curve analysis showed that the levels of GP73,PGK-1,Kep,Ktrans,and Ve as well as their combination had high predictive value for poor prognosis in prostate cancer patients after treatment,with AUC values of 0.797,0.766,0.772,0.729,0.733 and 0.967.Conclusion Serum GP73,PGK-1 levels and DCE-MRI parameters(Kep,Ktrans,Ve values)are significantly increased in prostate cancer patients and patients with poor prognosis,which can assist in the diagnosis of prostate cancer and early prediction of patients with poor prognosis.
Prostate cancerGolgi glycoprotein 73Phosphoglycerate kinase 1Dynamic contrast-enhanced magnetic resonance imagingPrognosisDiagnostic value
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